基因多态性与药物过敏反应相关性研究进展  

Research Progress of Relationship Between Gene Polymorphisms and Drug Allergy

作　　者：汤春艳 汪小海[1] 陈洁[1] 葛卫红[2] TANG Chunyan;WANG Xiaohai;CHEN Jie;GE Weihong(Department of Anesthesiology,Nanjing Drum Tower Hospital Affiliated to Medical College,Nanjing University,Nanjing 210008,China;Department of Pharmacy,Nanjing Drum Tower Hospital Affiliated to Medical College,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院麻醉科,南京210008 [2]南京大学医学院附属鼓楼医院药学部,南京210008

出　　处：《医药导报》2022年第3期334-338,共5页Herald of Medicine

摘　　要：药物过敏反应是由免疫介导的药物不良反应,多为突发和偶发且不可预测,其发生受环境和遗传等多种因素的影响。基因多态性研究可用于筛选过敏反应易感个体,在药物过敏反应预防和个体化治疗中发挥重要作用,因此成为近年来研究热点。该文阐述了药物过敏反应发生机制,并对近年来人类白细胞抗原(HLA)、白细胞介素(IL)和高亲和力IgE受体(FcεRI)基因多态性与药物过敏反应相关性研究进展进行综述,以期为进一步研究药物过敏易感基因提供理论基础。Allergic reaction to medications is a type of adverse drug reaction mediated by the immune system,with both genetic and environmental components determining disease expression.Although drug allergy is rare,it is accidental and less predictable in most cases.Genetic polymorphisms analysis exerts great functions in the prevention and individualized treatment of drug allergic reaction with genetic screening and has become one of the hot topics on allergic susceptibility.This paper describes the mechanisms in drug anaphylaxis and reviews the correlation between drug allergic reaction and human leukocyte antigen(HLA),interleukin(IL),and high-affinity IgE receptor(FcεRI)gene polymorphisms published in recent years,in order to provide a theoretical foundation to further explore the genetic susceptibility of drug anaphylaxis.

关 键 词：药物过敏反应 基因多态性 人类白细胞抗原 白细胞介素 高亲和力IGE受体 

分 类 号：R968[医药卫生—药理学] R969[医药卫生—药学]