白芍总苷与芍药苷抗衰老作用及其机制研究进展  

Research Progress of Anti-aging Effects and Mechanisms of Total Glucosides of Paeonyand Paeoniflorin

作　　者：金超 孙璇君 刘婷婷[2] JIN Chao;SUN Xuanjun;LIU Tingting(School of Pharmacy,Anhui Medical University,Hefei 230032,China;Department of Pharmacy,the First Affiliated Hospital of Anhui Medical University,the Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine,Hefei 230022,China;Department of Nephrology,the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230031,China)

机构地区：[1]安徽医科大学药学院,合肥230032 [2]安徽医科大学第一附属医院药剂科,国家中医药管理局中药化学三级实验室,合肥230022 [3]安徽中医药大学第一附属医院肾病科,合肥230031

出　　处：《医药导报》2022年第3期355-360,共6页Herald of Medicine

基　　金：国家自然科学基金资助项目(81903622);安徽省自然科学基金资助项目(1908085QH378);安徽省高校自然科学基金资助项目(KJ2020A0447)。

摘　　要：衰老是一种自然的生命过程,是机体内外多种因素共同作用的结果。近年来研究发现,白芍总苷(TGP)及其主要活性成分芍药苷(Pae)对各种衰老现象及年龄相关疾病有一定改善作用,进一步探索TGP及Pae的抗衰老作用及其机制,对提高老年人生活质量和减缓社会人口老龄化有重要意义。该文将从抗炎、免疫调节、改善睡眠、调节生物节律以及抗氧化等方面,探讨TGP及Pae对年龄相关疾病的治疗作用及其相关机制。Aging is a life process,which related to multiple factors.In recent years,there are some studies show that total glucoside of paeony(TGP)and paeoniflorin(Pae),the main active constituent of TGP,exhibit anti-aging effects on various age-related disease(ARD).The investigation to the anti-aging effects and mechanisms of TGP and Pae is significant for improving the life quality of the elderly and slowing down the population aging.This article reviews the current possible mechanisms relate to TGP or Pae in ARD from multiple aspects,such as anti-inflammatory,immunomodulatory,sleep improving,biorhythm regulation and oxidative stress.

关 键 词：白芍总苷 芍药苷 年龄相关疾病 抗衰老机制 

分 类 号：R285[医药卫生—中药学] R965[医药卫生—中医学]