原发性纤毛运动障碍并发男性不育的研究进展  

Primary ciliary dyskinesia complicated by male infertility:An update

作　　者：尹焯(综述)[1] 杨金瑞(审校)[1] YIN Zhuo;YANG Jin-rui(Department of Urology and Andrology,The Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,China)

机构地区：[1]中南大学湘雅二医院泌尿男科

出　　处：《中华男科学杂志》2021年第12期1124-1128,共5页National Journal of Andrology

摘　　要：原发性纤毛运动障碍(PCD)是一种常染色体隐性遗传病,基因突变导致纤毛结构异常或功能缺陷从而引起呼吸道疾病,男性PCD患者同时容易发生不育,发病机制可能在于基因突变同时导致了呼吸道纤毛和精子鞭毛发生了功能障碍。本文从微管结构、基因突变、辅助生殖结局等方面对其研究进展作一综述。Primary ciliary dyskinesia(PCD)is an autosomal recessive genetic disease.Gene mutation leads to ciliary structural abnormalities or functional defects,resulting in respiratory diseases.Male patients with PCD are prone to infertility,which pathogenically may be attributed to gene mutation-induced dysfunction of respiratory cilia and sperm flagella.This reviews focuses on the research progress in microtubule structure,gene mutation and outcomes of assisted reproduction relating to PCD complicated by male infertility.

关 键 词：原发性纤毛运动障碍 男性不育 基因 辅助生殖 

分 类 号：R698.2[医药卫生—泌尿科学]