普萘洛尔联合胺碘酮对恶性心律失常疗效观察  

Effect of Propranolol Combined with Amiodarone on Malignant Arrhythmia

作　　者：柏松[1] 赵东贤 许珊珊[1] 李娟[1] 苏晓薇 刘艳 BAI Song;ZHAO Dongxian;XU Shanshan;LI Juan;SU Xiaowei;LIU Yan(Huainan Union University School of Medicine,Anhui Huainan 232038;不详)

机构地区：[1]淮南联合大学医学院,安徽淮南232038 [2]安徽淮南卫生学校附属医院药剂科,安徽淮南232033

出　　处：《吉首大学学报（自然科学版）》2021年第5期61-64,共4页Journal of Jishou University(Natural Sciences Edition)

摘　　要：为探讨普萘洛尔联合胺碘酮对恶性心律失常患者炎性因子及QT间期离散度的影响.选择2018年2月至2020年6月在淮南联合大学医学院接受治疗的92例恶性心律失常患者作为研究对象,以随机数字表法分为观察组与对照组,各46例.对照组在常规治疗基础上加以盐酸胺碘酮片口服,观察组在对照组基础上加以盐酸普萘洛尔片口服.比较两组患者临床疗效、治疗前后炎性因子、治疗前后QT间期离散度及治疗期间不良反应.结果显示观察组总有效率为93.48%,显著高于对照组78.26%(P<0.05).治疗后两组患者肿瘤坏死因子α、白细胞介素6、C反应蛋白及QT间期离散度均较治疗前显著降低,但观察组降低更多(P<0.05).对照组共出现3例不良反应,与观察组出现的4例相比差异无统计学意义(P>0.05).说明普萘洛尔联合胺碘酮对恶性心律失常治疗较单独使用胺碘酮可明显增强临床疗效,缓解炎症反应、降低QT间期离散度且安全性较高.To investigate the effects of propranolol combined with amiodarone on inflammatory factors and QT interval dispersion in patients with malignant arrhythmia.92 patients with malignant arrhythmia treated in our hospital from February 2018 to June 2020 were randomly divided into two groups with 46 cases in each group.The control group was given amiodarone hydrochloride tablets on the basis of routine treatment,and the observation group was given propranolol hydrochloride tablets on the basis of the control group.The clinical efficacy,inflammatory factors,QT interval dispersion and adverse reactions were compared between the two groups.The results showed that the total effective rate in the observation group was 93.48%,which was higher than 78.26%in the control group(P<0.05).Tumor necrosis factor after treatmentα,Interleukin-6,C-reactive protein and QT interval dispersion were lower than those before treatment,but more in the observation group(P<0.05).There were 3 cases of adverse reactions in the control group,which had no significant difference compared with 4 cases in the observation group(P>0.05).It shows that propranolol combined with amiodarone can significantly enhance the clinical efficacy,alleviate inflammatory reaction,reduce QT interval dispersion and have higher safety than amiodarone alone.

关 键 词：普萘洛尔 胺碘酮 恶性心律失常 炎症因子 QT间期离散度 

分 类 号：TM344.1[电气工程—电机]