神经节苷脂联合阿糖腺苷对病毒性脑炎患儿血清选择素及免疫球蛋白的影响  

Effects of ganglioside combined with vidarabine on serum selectin and immunoglobulin in the children with viral encephalitis

作　　者：冯琴 唐川婷 FENG Qin;TANG Chuanting(Department of Pediatrics,Huaxi Guang’an Hospital of Sichuan University,Sichuan Guang’an 638000,China)

机构地区：[1]四川大学华西广安医院儿科,四川广安638000

出　　处：《药学服务与研究》2022年第1期24-28,共5页Pharmaceutical Care and Research

摘　　要：目的:研究神经节苷脂联合阿糖腺苷对病毒性脑炎患儿血清选择素和免疫球蛋白的影响。方法:选取2017年12月至2019年12月四川大学华西广安医院收治的100例病毒性脑炎患儿作为研究对象,按随机数字表法分为对照组和观察组,每组50例。观察组给予神经节苷脂联合阿糖腺苷治疗,对照组采用单纯阿糖腺苷治疗。分别在治疗前及治疗后观察患儿的临床症状,比较两组患儿血清中神经元特异性烯醇化酶(neuron-specific enolase,NSE),S100β蛋白,髓鞘碱性蛋白(myelin basic protein,MBP),L-选择素,P-选择素,免疫球蛋白IgA、IgE、IgG及IgM的水平。同时,记录并统计用药期间药品不良反应(ADRs)发生情况。结果:治疗后观察组总有效率显著高于对照组(98.00%vs 82.00%,P<0.05)。观察组呕吐缓解时间、意识恢复时间、退热时间、头痛缓解以及精神症状缓解时间均显著短于对照组(P<0.05)。治疗后两组血清NSE、S100β和MBP浓度均显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05)。观察组血清L-选择素、P-选择素水平显著低于对照组(P<0.05)。治疗后两组免疫球蛋白IgG升高(P<0.05),且观察组血清中免疫球蛋白IgG显著高于对照组(P<0.05)。免疫球蛋白IgE、IgA及IgM等治疗前后及组间比较无显著差异(P>0.05)。两组ADRs比较无显著性差异(P>0.05)。结论:神经节苷脂联合阿糖腺苷治疗病毒性脑炎患儿能够有效改善患者临床症状和神经损伤,降低血清选择素水平,升高血清中IgG的含量,增强患儿免疫功能,提高临床疗效,同时安全性较好。Objective:To explore the effects of ganglioside combined with vidarabine on the expression of serum selectin and immunoglobulin in the children with viral encephalitis.Methods:100 children with viral encephalitis treated in Huaxi Guang’an Hospital from December 2017 to December 2019 were enrolled and divided into the control group and the observation group by random number table,each consisting of 50.The patients in the observation group were treated with ganglioside combined with vidarabine,while the patients in the control group were treated with vidarabine alone.Cinical symptoms of the patients were evaluated and serum levels of neuron specific enolase(NSE),S100βprotein,myelin basic protein(MBP),L-selectin,P-selectin,immunoglobulin IgA,IgE,IgG and IgM were detected and compared between the two groups.Adverse drug reactions(ADRs)were monitored and statistically analyzed during medication.Results:After treatment,the total efficacy rate of the observation group was significantly higher than that of the control group(98.00%vs 82.00%,P<0.05).The vomiting remission time,consciousness recovery time,fever reduction time,headache relief time and mental symptom relief time in the patients of the observation group were significantly shorter than those of the control group(P<0.05).After treatment,the serum concentration levels of NSE,S100βand MBP in both groups were significantly lower than those before treatment,with those of the observation group being significantly lower than those of the control group(P<0.05).The serum levels of L-selectin and P-selectin in the observation group were significantly lower than those of the control group(P<0.05).The levels of immunoglobulin IgG in the two groups significantly increased after treatment(P<0.05),with the serum IgG of the observation group being significantly higher than that of the control group(P<0.05).No significant differences could be found in IgE,IgA and IgM both before and after treatment,when comparisons were made between the two groups(P>0.05).Marked differences

关 键 词：神经节苷脂 阿糖腺苷 病毒性脑炎 血清选择素 免疫球蛋白 

分 类 号：R969.4[医药卫生—药理学] R971[医药卫生—药学]