母胎界面树突状细胞在病理性妊娠中的作用机制研究进展  

Research Progress in Mechanism of Dendritic Cells on Maternal-fetal Interface in Pathological Pregnancy

作　　者：董浩旭 钟志艳 张青 胡茹楠 张明敏[1,2] 黄光英[2] 杨薇 DONG Haoxu;ZHONG Zhiyan;ZHANG Qing;HU Runan;ZHANG Mingmin;HUANG Guangying;YANG Wei(Department of Integrated Traditional Chinese and Western Medicine,Huazhong University of Science and Technology,Wuhan 430000,China;Institute of Integrated Traditional Chinese and Western Medicine,Huazhong University of Science and Technology,Wuhan 430000,China;Reproductive Medicine Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430000,China;Department of Traditional Chinese Medicine,Women′s Hospital School of Medicine Zhejiang University,Hangzhou 310000,China)

机构地区：[1]华中科技大学同济医学院附属同济医院中西医结合科,武汉430000 [2]华中科技大学同济医学院附属同济医院中西医结合研究所,武汉430000 [3]华中科技大学同济医学院附属同济医院生殖医学中心,武汉430000 [4]浙江大学医学院附属妇产科医院中医科,杭州310000

出　　处：《医学综述》2022年第3期444-448,455,共6页Medical Recapitulate

基　　金：国家自然科学基金(81803913);中国妇幼保健协会-华润三九中医中西医结合妇幼健康专项研究基金(ZXY2020A03)。

摘　　要：妊娠过程中,母胎界面少量的树突状细胞(DC)即可与母胎界面其他细胞滋养细胞、自然杀伤细胞(NK细胞)、巨噬细胞、调节性T细胞(Treg细胞)等相互联系、相互影响,通过参与调控辅助性T细胞(Th细胞)1/Th2平衡、促进Treg细胞增殖、调控NK细胞等免疫耐受环节发挥重要的免疫耐受调控作用。此外,DC还可以表达一系列信号分子、细胞因子和趋化因子等,直接或间接参与调控蜕膜化、血管生成、胎盘形成等过程。而DC的数量、分化和功能异常会直接或间接导致各种病理性妊娠,如自然流产、先兆子痫、HELLP综合征、异位妊娠等。During pregnancy,a small number of dendritic cell(DC)on the maternal-fetal interface,through mutual connection and influence with other cells on the interface[trophoblasts,natural killer cell(NK cell),macrophages,regulatory T cell(Treg cell),etc.],play a crucial regulatory role in many immune tolerance links,such as regulating the balance of helper T(Th cell)1/Th2 cytokines,promoting the proliferation of Treg cell,regulating NK cell and so on.In addition,DC can also express a series of signaling molecules,cytokines and chemokines etc.,directly or indirectly involved in the process of decidualization,angiogenesis and placenta formation.The abnormal quantity,differentiation and function of DC could directly or indirectly lead to various pathological pregnancy,such as spontaneous abortion,preeclampsia,HELLP syndrome,ectopic pregnancy,etc.

关 键 词：病理性妊娠 母胎界面 树突状细胞 自然流产 先兆子痫 HELLP综合征 异位妊娠 胎儿生长受限 

分 类 号：R714.2[医药卫生—妇产科学]