上海泗泾镇高血压患者同型半胱氨酸与血液生物化学指标相关性分析  

Analysis of the correlation of homocysteine and blood biochemical indexes in patients with hypertension in Sijing Community,Shanghai

作　　者：陆春华 许成美 董爱丽 LU Chunhua;XU Chengmei;DONG Aili(Community Department of Sijing Community Health Service Center of Songjiang District,Shanghai 201601,China)

机构地区：[1]上海市松江区泗泾镇社区卫生服务中心社区科,上海201601

出　　处：《上海医药》2022年第4期41-43,47,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:分析社区高血压患者合并高同型半胱氨酸血症(HHcy)的患病情况以及血浆同型半胱氨酸(Hcy)与空腹血糖、血脂、血尿酸、血肌酐、尿微量白蛋白等指标的关系。方法:收集上海市松江区泗泾镇2020年社区4657名高血压患者的体检结果,年龄中位数67岁,其中男性2298例,女性2359例。分析高血压合并HHcy的患病率和Hcy与空腹血糖、血脂、血尿酸、血肌酐、尿微量白蛋白等的关系。结果:高血压合并HHcy的检出率19.67%。HHcy患者的年龄、尿酸、肌酐高于非HHcy患者,差异有统计学意义(P<0.05)。HHcy患者的胆固醇、低密度脂蛋白胆固醇低于非HHcy患者,差异有统计学意义(P<0.05)。Pearson相关性分析显示,Hcy与年龄、尿酸、肌酐呈正相关,与总胆固醇、低密度脂蛋白胆固醇呈负相关,差异均有统计学意义(均P<0.05)。Hcy与BMI、三酰甘油和尿微量白蛋白没有相关性。结论:上海松江区泗泾镇高血压人群HHcy患病率较高,Hcy水平与年龄、尿酸、肌酐呈正相关,与总胆固醇、低密度脂蛋白胆固醇呈负相关。Objective:To analyze the prevalence of hypertensive patients complicated with hyperhomocysteinemia(HHcy)in the community and the relationship between plasma homocysteine(Hcy)and fasting blood glucose,blood lipids,blood uric acid,blood creatinine,urine microalbumin and other indicators.Methods:The physical examination results of 4657 hypertensive patients in Sijing Community,Songjiang District,Shanghai in 2020 were collected,and the median age was 67 years,including 2298 males and 2359 females.The prevalence of hypertension complicated with HHcy and the relationship between Hcy and fasting blood glucose,blood lipids,blood uric acid,blood creatinine,urine microalbumin,etc.Results:The detection rate of hypertension complicated with HHcy was 19.67%.The age,uric acid,and creatinine of HHcy patients were higher than those of non-HHcy patients,and the difference was statistically significant(P<0.05).The cholesterol and low-density lipoprotein cholesterol of HHcy patients were lower than those of non-HHcy patients,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that Hcy was positively correlated with age,uric acid and creatinine,it was negatively correlated with total cholesterol and low-density lipoprotein cholesterol,and the differences were statistically significant(all P<0.05).Hcy was not correlated with BMI,triacylglycerol and urinary microalbumin.Conclusion:The prevalence rate of HHcy is higher in Sijing Community,Songjiang District,Shanghai,the level of Hcy is positively correlated with age,uric acid and creatinine,but is negatively correlated with total cholesterol and low density lipoprotein cholesterol.

关 键 词：高血压 同型半胱氨酸 血液生物化学指标 

分 类 号：R58[医药卫生—内分泌]