10 MeV电子束辐照医疗保健产品剂量控制应用初探  

Dose control and preliminary applications of radiation sterilization of medical and health care products using 10 MeV electron beams

作　　者：赵延军 彭伟 柳玲 吕均涛 孙芳超 靖坤 刘卫霞 付玉宸 ZHAO Yanjun;PENG Wei;LIU Ling;LYU Juntao;SUN Fangchao;JING Kun;LIU Weixia;FU Yuchen(Shandong Vanform High Energy Physics Technology Corporation,Jinan 250101,China)

机构地区：[1]山东蓝孚高能物理技术股份有限公司,济南250101

出　　处：《辐射研究与辐射工艺学报》2022年第1期72-79,共8页Journal of Radiation Research and Radiation Processing

摘　　要：为进一步完善医疗保健产品辐照加工工艺,对10 MeV电子束单双面吸收剂量分布进行了详细测量和分析。采用密度不同的PE板、雪弗板和高密度高压泡沫板等均匀材料,测量并分析了电子束的最佳穿透深度和深度剂量分布。结果表明:双面辐照时剂量不均匀度为1.0~2.6,医疗保健产品的最大可接受剂量辐照梯度不小于最低灭菌剂量的2.6倍;根据最大可接受剂量与最低灭菌剂量比值,可以选择电子束剂量深度曲线的区域,或者采取优化包装形式、改善辐照方式、产品生产过程预处理等方法控制医疗保健产品的吸收剂量。本研究对于指导医疗保健产品辐照应用有着非常重要的意义。The single-and double-side dose distributions of 10 MeV electron beam irradiation were measured and extensively analyzed to optimize the irradiation process for medical and health care products.To this end,the optimal penetration depth and depth dose distribution curves of an electron beam were measured and analyzed in three uniform materials with varying densities:a PE board,Chevrolet board,and high-density high-pressure foam board.The results demonstrated that the dose uniformity ratio range of double-side irradiation was approximately 1.0-2.6.The maximum acceptable dose variation for medical and health care products should be a minimum of 2.6 times that of the minimum sterilization dose.A region on the depth curve of an electron beam dose could be selected according to the ratio between the maximum acceptable dose and the minimum sterilization dose;alternatively,the absorbed dose for health care products could be controlled by optimizing the packaging form to improve the irradiation mode and pretreatment of the product.This study demonstrated the importance of effective radiation sterilization for medical and health care products.

关 键 词：电子束 加速器 医疗保健产品 最大可接受剂量 剂量控制 剂量不均匀度 

分 类 号：TL99[核科学技术—核技术及应用] TL53