血清miR-208在慢性心力衰竭中的表达及临床意义  

Expression and clinical significance of serum miR-208 in chronic heart failure

作　　者：李岗峰 刘璐 李刘文 LI Gang-feng;LIU Lu;LI Liu-wen(Department of Emergency,Yulin No.2 Hospital,Yulin 719000,Shaanxi,CHINA)

机构地区：[1]榆林市第二医院急诊科,陕西榆林719000

出　　处：《海南医学》2022年第4期417-420,共4页Hainan Medical Journal

基　　金：陕西省科技厅科技攻关项目(编号:2018KS-14-03)。

摘　　要：目的探讨血清miR-208在慢性心力衰竭中的表达及其临床意义。方法选取2018年6月至2021年1月期间榆林市第二医院急诊科收治的慢性心力衰竭(CHF)患者150例,根据美国纽约心脏病协会心功能(NYHA)分级分为A组(NYHAⅠ~Ⅱ级)46例,B组(NYHAⅢ级)55例和C组(NYHAⅣ级)49例,同时选择同期体检的无CHF患者46例为对照组,Real-time PCR检测血清miR-208水平,收集患者N端前脑钠素(NT-proBNP),左心室射血分数(LVEF),左心房(LA)直径和心胸比率等临床病理资料。使用Pearson检验评价患者临床病理参数与血清miR-208表达之间的相关性。结果四组受检者的年龄,性别,血压,高血压病史或糖尿病病史,BMI比较差异均无统计学意义(P>0.05);四组受检者的血清空腹血糖、总胆固醇(TC)、甘油三酯(TG)和肌酐(Cr)水平比较差异亦均无统计学意义(P>0.05);A、B、C组患者miR-208相对表达均较对照组明显提高,且miR-208表达水平随心功能NYHA分级升高而升高,差异均有统计学意义(P<0.05);四组受检者的NT-proBNP、LVEF、LA直径和心胸比率比较差异均有统计学意义(P<0.05),其中三组患者的NT-proBNP水平较对照组升高,LVEF水平降低,LA直径升高以及心胸比率增加,差异均有统计学意义(P<0.05);此外,患者NT-proBNP水平随心功能NYHA分级升高而升高,LVEF随心功能NYHA分级升高而降低,LA直径随心功能NYHA分级升高而升高,差异均有统计学意义(P<0.05);血清miR-208相对表达与患者NT-proBNP,LA直径正相关(r=0.784,0.524,P<0.05),与LVEF负相关(r=-0.375,P<0.05)。结论CHF患者的血清miR-208水平可作为评估其严重程度的潜在生物标志物。Objective To investigate the expression and clinical significance of serum miR-208 in chronic heart failure.Methods A total of 150 patients with chronic heart failure(CHF)treated in Department of Emergency,Yulin No.2 Hospital from June 2018 to January 2021 were selected.According to the New York Heart Association Heart function(NYHA)classification,they were devided into group A(NYHAⅠ-Ⅱ,n=46),group B(NYHAⅢ,n=55),and group C(NYHAⅣ,n=49).At the same time,46 patients without CHF in the same period of physical examination were selected as the control group.The serum miR-208 level was detected by Real-time PCR.The clinicopathological data of N-terminal pro-brain natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF),left atrium(LA)diameter,and cardiothoracic ratios were collected.Pearson test were undertaken to evaluate the correlation between clinicopathological parameters and serum miR-208 expression in patients.Results There were no significant differences in age,gender,blood pressure,history of hypertension or diabetes,and BMI among the four groups of subjects(P>0.05).There was no statistically significant differences in serum fasting blood glucose,total cholesterol(TC),triglyceride(TG),and creatinine(Cr)levels among the four groups(P>0.05).The relative expression of miR-208 in group A,group B,and group C were significantly higher than that in the control group,and the expression level of miR-208 increased with the increase of the NYHA classification,and the difference was statistically significant(P<0.05).There were statistically significant differences in NT-proBNP,LVEF,LA diameter,and cardiothoracic ratio among the four groups(P<0.05).Compared with the control group,the three groups of patients had increased NT-proBNP levels,decreased LVEF levels,increased LA diameters,and increased cardiothoracic ratios,with statistically significant differences(P<0.05).In addition,the level of NT-proBNP increased with the increase of NYHA classification,LVEF decreased with the increase of NYHA classifi

关 键 词：内源性小非编码RNA-208 心力衰竭 N端前脑钠素 左心室射血分数 左心房直径 心胸比率 

分 类 号：R541.6[医药卫生—心血管疾病]