慢性宫颈炎患者HPV感染状况、基因型分布及其与阴道微生态指标的相关性研究  

HPV infection,genotypes distribution of patients with chronic cervicitis and their correlation with vaginal micro-ecology indexes

作　　者：张海琴 刘娟娟 娄俊丽 雷申琼 ZHANG Hai-qin;LIU Juan-juan;LOU Jun-li;LEI Shen-qiong(Department of Obstetrics and Gynecology,Tongchuan Maternal and Child Health Hospital,Tongchuan 727000,Shaanxi,CHINA)

机构地区：[1]铜川市妇幼保健院妇产科,陕西铜川727000

出　　处：《海南医学》2022年第4期464-467,共4页Hainan Medical Journal

摘　　要：目的研究慢性宫颈炎患者人乳头瘤病毒(HPV)感染状况、基因型分布及其与阴道微生态指标的相关性。方法选取2018年1月至2020年12月于铜川市妇幼保健院妇科门诊收治的140例慢性宫颈炎患者作为病例组,另选取同期在我院体检的60例正常健康妇女作为正常组,比较两组妇女的不同HPV基因型分布、HPV感染情况和阴道微生态指标(乳酸杆菌、阴道pH、白细胞酯酶、唾液酸甘酶),采用Spearman相关分析高危型HPV感染与慢性宫颈炎患者阴道微生态指标之间的相关性。结果病例组患者检出HPV阳性72例(51.43%),其中59例为单一感染,13例为多重感染;病例组患者的HPV6、HPV16检出率明显高于正常组,差异均有统计学意义(P<0.05);病例组患者的乳酸杆菌多分布、阴道pH>4.5占比分别为62.86%,60.00%,均高于正常组的36.67%,43.33%,差异均有统计学意义(P<0.05);病例组患者的白细胞酯酶阳性率、唾液酸甘酶阳性率分别为69.29%和61.43%,明显高于正常组的48.33%和45.00%,差异均有统计学意义(P<0.05);高危型患者的乳酸杆菌多分布占比为34.78%,明显低于低危型患者的66.67%,差异有统计学意义(P<0.05);高危型患者的白细胞酯酶、唾液酸甘酶阳性率分别为56.52%和60.87%,明显高于低危型的27.78%和33.33%,差异均有统计学意义(P<0.05);高危型HPV感染与慢性宫颈炎患者的乳酸杆菌、白细胞酯酶、唾液酸甘酶呈正相关(r=0.684、0.523、0.621,P<0.05)。结论慢性宫颈炎患者HPV感染率较高,以单一感染为主,复合型感染以高危型多重感染为主,且慢性宫颈炎患者存在阴道微生态失衡,高危型HPV感染与阴道微生态指标存在较强的相关性。Objective To study human papillomavirus(HPV)infection,genotypes distribution in patients with chronic cervicitis and its correlation with vaginal micro-ecology indexes.Methods During the period from January2018 to December 2020,140 patients with chronic cervicitis admitted to Department of Obstetrics and Gynecology,Tongchuan Maternal and Child Health Hospital were enrolled as the study group,while 60 healthy women undergoing physical examination were enrolled as control group.The distribution of different HPV genotypes,HPV infection and vaginal micro-ecology indexes(Lactobacillus,vaginal pH,leukocyte esterase,neuraminidase)were compared between the two groups.The correlation among high-risk HPV infection and vaginal micro-ecology indexes was analyzed by Spearman correlation analysis.Results In the 140 patients with chronic cervicitis,there were 72 cases(51.43%)with positive HPV,including 59 cases(42.14%)with single infection and 13 cases(9.29%)with multiple infection.The detection rates of HPV6 and HPV16 in the study group were significantly higher than those in the control group(P<0.05).The multi-distribution of Lactobacilli,vaginal pH>4.5 in the study group were 62.86%and 60.00%,significantly higher than 36.67%and 43.33%in the control group(P<0.05).The positive rates of leukocyte esterase and neuraminidase in the study group were 69.29%and 61.43%,significantly higher than 48.33%,45.00%in the control group(P<0.05).The multi-distribution of Lactobacillus in high-risk patients were significantly lower than that in low-risk patients:34.78%vs66.67%,P<0.05.The positive rates of leukocyte esterase and neuraminidase in high-risk patients were 56.52%and60.87%,significantly higher than 27.78%and 33.33%in low-risk patients(P<0.05).High-risk HPV infection was positively correlated with vaginal micro-ecology indexes(Lactobacillus,leukocyte esterase,neuraminidase)in patients with chronic cervicitis(r=0.684,0.523,0.621,P<0.05).Conclusion The incidence of HPV infection is relatively higher in patients with chronic cervicitis,m

关 键 词：宫颈炎 人乳头瘤病毒 基因型 乳酸杆菌 阴道pH 白细胞酯酶 唾液酸甘酶 

分 类 号：R711.32[医药卫生—妇产科学]