定向透药联合妇科千金胶囊治疗湿热瘀阻型盆腔炎症性疾病的效果  

Effect of directional drug penetration combined with Fuke Qianjin Capsules in the treatment of pelvic inflammatory disease with damp heat stasis type

作　　者：王群 罗明艳 WANG Qun;LUO Mingyan(Department of Gynaecology,Xindu Hospital of Traditional Chinese Medicine,Sichuan Province,Chengdu 610000,China;Department of Obstetrics and Gynecology,Western Theater General Hospital,Sichuan Province,Chengdu 610000,China)

机构地区：[1]成都市新都区中医医院妇科,四川成都610000 [2]西部战区总医院妇产科,四川成都610000

出　　处：《中国医药导报》2022年第2期75-79,共5页China Medical Herald

基　　金：四川省科技计划项目(17YYJC0043)。

摘　　要：目的探讨定向透药联合妇科千金胶囊治疗湿热瘀阻型盆腔炎症性疾病(PID)的效果。方法选取2019年1月至2020年10月成都市新都区中医医院收治的湿热瘀阻型PID患者91例,按照随机数字表法分为对照组(45例,妇科千金胶囊+常规治疗)和研究组(46例,定向透药+妇科千金胶囊+常规治疗)。比较两组临床疗效,中医症状评分,血清炎症因子[白细胞介素-6(IL-6)、IL-2、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)],血液流变学指标(血浆黏度、低切全血黏度、纤维蛋白原、高切全血黏度、血细胞比容),盆腔积液深度,盆腔炎性包块直径;观察治疗期间不良反应发生情况。结果研究组临床总有效率高于对照组(P<0.05)。治疗后,两组下腹刺痛、腰骶胀痛、经期延长、月经量增多、神疲乏力评分低于治疗前,且研究组低于对照组(P<0.05)。治疗后,两组IL-6、IL-2、TNF-α、hs-CRP水平低于治疗前,且研究组低于对照组(P<0.05)。治疗后,两组血浆黏度、低切全血黏度、纤维蛋白原、高切全血黏度、血细胞比容低于治疗前,且研究组低于对照组(P<0.05)。治疗后,两组盆腔积液深度、盆腔炎性包块直径低于治疗前,且研究组低于对照组(P<0.05)。治疗期间两组均未出现严重不良反应。结论定向透药联合妇科千金胶囊治疗湿热瘀阻型PID患者具有较好的临床效果,可降低炎症反应,改善血液流变学,减轻临床症状,且安全性高。Objective To investigate the effect of directional drug penetration combined with Fuke Qianjin Capsules in the treatment of pelvic inflammatory disease(PID)with damp heat stasis type.Methods A total of 91 PID patients with damp heat stasis type who were admitted to Xindu Hospital of Traditional Chinese Medicine from January 2019 to October 2020 were selected.They were divided into control group(45 cases,Fuke Qianjin Capsules+conventional treatment)and study group(46 cases,directional drug penetration+Fuke Qianjin Capsules+conventional treatment)by random number table method.The clinical efficacy,traditional Chinese medicine symptom score,serum inflammatory factors(interleukin-6[IL-6],IL-2,tumor necrosis factor-α[TNF-α],and high-sensitivity C-reactive protein[hsCRP]),hemorheology index(plasma viscosity,low shear whole blood viscosity,fibrinogen,high shear whole blood viscosity,and hematocrit),pelvic effusion depth,pelvic inflammatory mass diameter were compared between two groups;the incidence of adverse reactions during treatment was observed.Results The total effective rate of study group was higher than that of control group(P<0.05).After treatment,the scores of lower abdominal pain,lumbosacral pain,prolonged menstrual period,increased menstrual volume,and mental fatigue in two groups were lower than those before treatment,and study group was lower than control group(P<0.05).After treatment,the levels of serum IL-6,IL-2,TNF-α,and hs-CRP of two groups were lower than those before treatment,and study group was lower than control group(P<0.05).After treatment,the plasma viscosity,low shear whole blood viscosity,fibrinogen,high shear whole blood viscosity,and hematocrit of two groups were lower than those before treatment,and study group was lower than control group(P<0.05).After treatment,the pelvic effusion depth and pelvic inflammatory mass diameter in two groups were lower than those before treatment,and study group was lower than control group(P<0.05).There were no serious adverse reactions in two groups du

关 键 词：妇科千金胶囊 定向透药 盆腔炎症性疾病 湿热瘀阻型 临床研究 

分 类 号：R711.33[医药卫生—妇产科学]