双嘧达莫联合IVIG及阿司匹林治疗儿童川崎病的效果及对T淋巴细胞亚群、凝血功能和炎症因子水平的影响  

Effect of Dipyridamole combined with IVIG and Aspirin in the treatment of children with Kawasaki disease and its effect on T lymphocyte subsets,coagulation function and inflammatory factor levels

作　　者：李虹媛 张辉 张建明 LI Hongyuan;ZHANG Hui;ZHANG Jianming(Department of Pediatrics,Fuyang Women’s and Children’s Hospital,Anhui Province,Fuyang 236000,China)

机构地区：[1]安徽省阜阳市妇女儿童医院儿科,安徽阜阳236000

出　　处：《中国医药导报》2022年第2期88-91,共4页China Medical Herald

摘　　要：目的探讨双嘧达莫联合静脉注射免疫球蛋白(IVIG)及阿司匹林治疗儿童川崎病(KD)的效果及对T淋巴细胞亚群、凝血功能、炎症因子水平的影响。方法选择2018年1月至2021年1月安徽省阜阳市妇女儿童医院儿科收治的80例KD患儿,采用随机数字表法分为观察组和对照组,每组40例。对照组给予阿司匹林+IVIG治疗,观察组在对照组基础上联合双嘧达莫治疗。比较两组临床疗效;比较两组治疗前后T淋巴细胞亚群、凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fbg)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平;记录治疗期间不良反应的发生情况。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组CD4^(+)、CD4^(+)/CD8^(+)低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组CD8^(+)高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后,两组PT、TT、APTT与治疗前比较,差异无统计学意义(P>0.05);两组Fbg水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组TNF-α、IL-6、CRP水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论双嘧达莫联合IVIG及阿司匹林治疗KD可有效改善患儿的免疫功能、凝血功能及炎症水平,安全性高,效果显著,建议临床推广运用。Objective To investigate the effect of Dipyridamole combined with Intravenous Immunoglobulin(IVIG)and Aspirin in the treatment of children with Kawasaki disease(KD)and its effect on T lymphocyte subsets,coagulation function,and inflammatory factor levels.Methods A total of 80 children with KD admitted to Department of Pediatrics,Fuyang Women’s and Children’s Hospital of Anhui Province from January 2018 to January 2021 were selected,they were divided into observation group and control group,with 40 cases in each group.The control group was treated with Aspirin and IVIG,and observation group was treated with Dipyridamole on the basis of control group.The clinical efficacy of two groups was compared;T lymphocyte subsets,prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(Fbg)and the levels of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)were compared between two groups before and after treatment;the occurrence of adverse reactions during treatment was recorded.Results The total effective rate of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).After treatment,CD4^(+)and CD4^(+)/CD8^(+)in observation group were lower than those before treatment,and observation group was lower than control group,and the differences were statistically significant(P<0.05);CD8^(+)in both groups were higher than those before treatment,and observation group was higher than control group,and the differences were statistically significant(P<0.05).After treatment,there were no significant differences in PT,TT,and APTT between two groups compared with before treatment(P>0.05);the level of Fbg in two groups were lower than those before treatment,and observation group was lower than control group,and the differences were statistically significant(P<0.05).After treatment,the levels of TNF-α,IL-6,and CRP in two groups were lower than those before treatment,and observation group was lower than control g

关 键 词：川崎病 双嘧达莫 静脉注射免疫球蛋白 T淋巴细胞亚群 凝血功能 炎症因子 

分 类 号：R725.4[医药卫生—儿科]