促胃肠道动力药治疗糖尿病胃肠功能紊乱的临床治疗效果  

Clinical Effect of Gastrointestinal Motility Drugs on Diabetic Gastrointestinal Dysfunction

作　　者：蒲蕙 黄文宝 PU Hui;HUANG Wenbao(Department of Gastroenterology,Zhangzhou Hospital,Fujian Medical University,Zhangzhou,Fujian Province,363000 China)

机构地区：[1]福建医科大学附属漳州市医院消化内科,福建漳州363000

出　　处：《糖尿病新世界》2021年第24期182-185,共4页Diabetes New World Magazine

摘　　要：目的对糖尿病胃肠功能紊乱患者临床治疗情况进行探究,以期明确促胃肠道动力药的有效性、可行性。方法选取该院消化内科2019年5月—2021年5月收治的92例糖尿病胃肠功能紊乱患者为研究对象,按照随机数表法分组:对照组(46例,在常规对症治疗基础上辅以谷维素)、观察组(46例,在常规治疗基础上辅以促胃肠道动力药),为期3个月,对比临床疗效,包括总有效率、血浆胃肠激素水平、胃排空时间、生活质量、复发率,其中生活质量的评价工具为生活质量综合评定问卷(generic quality of life inventory 74,GQOLI-74)。结果用药3个月后,观察组总有效率95.65%较对照组76.09%高,差异有统计学意义(P<0.05);观察组血清MTL、GAS水平较对照组低,差异有统计学意义(P<0.05);观察组胃排空时间较对照组减短,差异有统计学意义(P<0.05);观察组GQOLI-74总评分较对照组高,差异有统计学意义(P<0.05);观察组复发率2.17%较对照组13.04%低,差异有统计学意义(P<0.05)。结论在糖尿病胃肠功能紊乱患者治疗中辅以促胃肠道动力药,可获取更高的治疗效果,改善胃肠功能,优化生活质量,以及降低病情复发率,值得优选。Objective To investigate the clinical treatment of patients with diabetic gastrointestinal dysfunction,in order to clarify the effectiveness and feasibility of gastrointestinal motility drugs.Methods Ninety-two patients with diabetic gastrointestinal dysfunction from May 2019 to May 2021 in the Department of Gastroenterology of the hospital were selected as the research objects.Grouped according to the random number table:control group(46 cases,supplemented with oryzanol on the basis of conventional symptomatic treatment),observation group(46 cases,supplemented with gastrointestinal motility drugs on the basis of conventional treatment).The clinical efficacy was compared for 3 months,including total effective rate,plasma gastrointestinal hormone levels,gastric emptying time,quality of life,and recurrence rate.The quality of life evaluation tool is the comprehensive quality of life assessment questionnaire(generic quality of life inventory 74,GQOLI-74).Results After 3 months of treatment,the total effective rate of the observation group was 95.65%higher than that of the control group 76.09%,and the difference was statistically significant(P<0.05).The serum MTL and GAS levels of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).The observation group gastric emptying time was shorter than that of the control group,and the difference was statistically significant(P<0.05).The total score of GQOLI-74 in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The recurrence rate of the observation group was 2.17%lower than that of the control group 13.04%,and the difference was statistically significant(P<0.05).Conclusion The supplementation of gastrointestinal motility drugs in the treatment of patients with diabetic gastrointestinal dysfunction can achieve higher therapeutic effects,improve gastrointestinal function,optimize the quality of life,and reduce the recurrence rate of the d

关 键 词：糖尿病 胃肠功能紊乱 促胃肠道动力药 效果 

分 类 号：R58[医药卫生—内分泌]