达州地区RhD阳性健康献血者RhCcEe分布频率调查  

Distribution frequency of RhCcEe among RhD-positive healthy blood donors in Dazhou area

作　　者：潘枫[1] 刘娟[1] 熊德琼 张泽君[1] 冯晨程 李维 王春泽 周晓瑜 祝富铭 PAN Feng;LIU Juan;XIONG De-qiong;ZHANG Ze-jun;FENG Chen-cheng;LI Wei;WANG Chun-ze;ZHOU Xiao-yu;ZHU Fu-ming(Department of Blood Transfusion,Dazhou Hospital of Integrated Traditional Chinese and Western Medicine,Dazhou 635000,Sichuan,China)

机构地区：[1]达州市中西医结合医院输血科,四川达州635000

出　　处：《川北医学院学报》2022年第2期232-235,共4页Journal of North Sichuan Medical College

摘　　要：目的:探究达州地区RhD阳性健康献血者RH表型抗原CcEe的分布频率。方法:简单随机抽样法选取达州地区1496例RhD阳性健康献血者的血液样本,采用微柱凝胶法进行Rh血型抗原检测,计算Rh血型各表型频率,并与国内其他地区Rh血型表型分布情况进行比较。结果:1496例RhD阳性健康献血者中,A型548例,B型317例,O型504例,AB型127例。共检出8种Rh血型抗原分型,检出频率从大到小依次为:CCDee(48.46%)>CcDEe(33.76%)>CcDee(8.56%)>ccDEE(5.61%)>ccDEe(2.74%)>CcDEE(0.40%)>CCDEe(0.27%)>ccDee(0.20%);不同血型献血者Rh抗原表型的检出频率比较,差异无统计学意义(P>0.05)。Rh抗原阳性率从大到小依次为:e(93.98%)>C(91.44%)>c(51.27%)>E(42.78%);不同血型献血者Rh抗原分布频率比较,差异无统计学意义(P>0.05)。达州地区RhD阳性健康献血者的Rh血型表型分布与北京、兰州、湖北和福州等地区分布情况接近。结论:达州地区RhD阳性健康献血者Rh表型抗原以CCDee、CcDEe型最为常见,C、e抗原分布频率较高,Rh表型分布特征与国内部分地区相似。Objective:To explore the distribution frequency of RhCcEe in RhD-positive healthy blood donors in Dazhou area.Methods:1,496 blood samples from RhD-positive healthy blood donors in Dazhou area were selected by simple random sampling method.The Rh blood group antigens were detected by micro-column gel method.The frequency of each Rh blood group phenotype was calculated and compared with the distribution of Rh blood group phenotypes in other regions of the country.Results:Among 1,496 RhD positive healthy blood donors,the blood types included type A(548 cases),type B(317 cases),type O(504 cases)and type AB(127 cases).A total of 8 types of Rh blood group antigens were detected,and the order of detection frequency was as follows:CCDee(48.46%)>CcDEe(33.76%)>CcDee(8.56%)>ccDEE(5.61%)>ccDEe(2.74%)>CcDEE(0.40%)>CCDEe(0.27%)>ccDee(0.20%).There was no significant difference in the detection frequency of Rh antigen phenotype among blood donors with different blood types(P>0.05).The positive rate of Rh antigen was as follows:e(93.98%)>C(91.44%)>c(51.27%)>E(42.78%).There was no statistically significant difference in the distribution frequency of Rh antigen among blood donors with different blood types(P>0.05).The distribution of Rh blood type phenotype among RhD-positive healthy blood donors in Dazhou area was similar to that in Beijing,Lanzhou,Hubei and Fuzhou.Conclusion:CCDee and CcDEe are the most common types of Rh phenotype antigens among RhD-positive healthy blood donors in Dazhou area,and the distribution frequencies of C and e antigens are relatively higher.The distribution characteristics of Rh phenotype in Dazhou area are similar to those in some parts of the country.

关 键 词：输血 血型抗原 RH阳性 血清学表型 CcDEe CCDee 

分 类 号：R457.1[医药卫生—治疗学] R392.11[医药卫生—临床医学]