基于静息态度中心度的T2DM共病抑郁脑功能研究  

Brain function study in T2DM comorbidity depression based on resting state degree centrality

作　　者：李周乐 赵莲萍[2] 黄刚[2] 柳瑞芳 田静 陆亚姗 韦佳[3] LI Zhoule;ZHAO Lianping;HUANG Gang;LIU Ruifang;TIAN Jing;LU Yashan;WEI Jia(The First Clinical Medical College of Gansu University of Chinese Medicine(Gansu Provincial Hospital),Lanzhou 730000,China;Department of Radiology,Gansu Provincial Hospital,Lanzhou 730000,China;Department of Functional Division,Gansu Province People Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院(甘肃省人民医院),兰州730000 [2]甘肃省人民医院放射科,兰州730000 [3]甘肃省人民医院功能科,兰州730000

出　　处：《磁共振成像》2022年第2期37-41,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(81901724、81860306);甘肃省自然科学基金(20JR5RA156、21JR7RA593);甘肃省人民医院院内科研项目(19SYPYA-2);中国科学院2020年度“西部青年学者”项目。

摘　　要：目的采用静息态功能磁共振成像基于图论的度中心度(degree centrality,DC)方法,重点探讨2型糖尿病共病抑郁(type 2 diabetes comorbid depression,T2DD)脑功能网络连接属性的异常模式,进一步阐明T2DD的神经影像学机制。材料与方法前瞻性纳入T2DD者52例、2型糖尿病(type 2 diabetes mellitus,T2DM)不伴抑郁者59例和健康对照者57例行头颅MR扫描,采集临床变量、评测认知心理量表。比较三组间全脑DC值,并提取差异显著脑区的DC值与临床变量、认知心理量表评分行相关分析。结果与健康对照组和T2DM不伴抑郁组相比,T2DD组有更低的认知评分、抑郁评分和焦虑评分;与健康对照组相比,T2DM不伴抑郁组右后扣带回DC值减低,T2DD组右颞横回DC值增加(高斯随机场校正,体素水平P<0.005,簇水平P<0.05),T2DM不伴抑郁组及T2DD组DC值与临床变量和认知心理量表评分间未发现显著相关。结论T2DD患者伴有更严重的情绪异常和认知功能受损,在静息状态下,其右侧颞横回脑功能网络拓扑属性异常,可能是T2DD脑损害的潜在神经影像生物学标记。Objective:To explore the abnormal patterns of brain functional networks in type 2 diabetes comorbid depression(T2 DD)by using Degree Centrality(DC)method of resting state functional magnetic resonance imaging.To further elucidate the neuroimaging mechanisms of T2 DD.Materials and Methods:Fifty-six T2 DD patients,59 type 2 diabetes mellitus(T2 DM)patients without depression and 57 healthy volunteers were prospectively enrolled.The whole brain DC values of the three groups were compared,and the correlation analysis between the DC values of the brain regions with significant differences and clinical variables and cognitive psychological scale was extracted.Results:Compared with control group and T2 DM without depression group,T2 DD group had lower cognitive score,depression score and anxiety score.Compared with the control group,the DC value of the right posterior cingulate gyrus decreased in T2 DM without depression group,and the DC value of the right transverse temporal gyrus increased in T2 DD group(GRF correction,voxel P<0.001,cluster P<0.05),no correlation was found between the DC values of these brain regions and the clinical data and the cognitive psychosocial scale scoring.Conclusions:T2 DD patients are associated with more severe emotional abnormalities and cognitive impairment.In resting state,abnormal topology of the functional network of the right transverse temporal gyrus may be a potential neuroimaging biological marker of T2 DD brain damage.

关 键 词：糖尿病 2型 抑郁 共病 脑功能成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.24[医药卫生—诊断学]