加减补阳还五汤联合地奥司明治疗下肢慢性静脉功能不全临床研究  

Clinical Study on Modified Buyang Huanwu Tang Combined with Diosmin for Chronic Venous Insufficiency of Lower Limbs

作　　者：田晋嗣[1] 戴朝波 兰金耀[1] 项华明[1] TIAN Jinsi;DAI Chaobo;LAN Jinyao;XIANG Huaming

机构地区：[1]丽水市中医院普外科,浙江丽水323000

出　　处：《新中医》2022年第2期19-22,共4页New Chinese Medicine

摘　　要：目的:观察加减补阳还五汤联合地奥司明治疗下肢慢性静脉功能不全的临床效果。方法:选取52例下肢慢性静脉功能不全患者,采用随机数字表法分为治疗组与对照组各26例。对照组给予地奥司明治疗,治疗组在对照组的基础上给予加减补阳还五汤治疗。治疗8周后,观察2组临床疗效、症状评分及血清炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平变化。结果:治疗组总有效率为92.31%,对照组为69.23%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组疼痛、沉重感、肿胀、深静脉血流反流时间评分比较,差异无统计学意义(P>0.05);治疗后,2组上述各项症状评分均较治疗前降低(P<0.05),且治疗组各项评分均低于对照组(P<0.05)。治疗前,2组血清IL-6、TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,2组IL-6、TNF-α水平均较治疗前降低(P<0.05),且治疗组IL-6、TNF-α水平均低于对照组(P<0.05)。结论:加减补阳还五汤联合地奥司明治疗下肢慢性静脉功能不全疗效显著,可有效缓解患者临床症状,减轻机体炎症反应。Objective:To observe the clinical effect of modified Buyang Huanwu tang combined with diosmin for chronic venous insufficiency of lower limbs.Methods:A total of 52 cases of patients with chronic venous insufficiency of lower limbs were divided into the treatment group and the control group according to the random number table method,with 26 cases in each group.The control group was treated with diosmin,and the treatment group was additionally treated with modified Buyang Huanwu tang based on the treatment of the control group.After eight-week treatment,the clinical effects and symptoms scores as well as changes in levels of inflammatory factors including interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in serum in the two groups were observed.Results:The total effective rate was 92.31%in the treatment group and 69.23%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of pain,a sense of heaviness,swelling and reflux time of deep vein blood flow between the two groups(P>0.05);after treatment,the above symptom scores in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the treatment group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of levels of inflammatory factors including IL-6 and TNF-αin serum between the two groups(P>0.05);after treatment,the levels of IL-6 and TNF-αin the two groups were decreased when compared with those before treatment(P<0.05),and the levels of IL-6 and TNF-αin the treatment group were lower than those in the control group(P<0.05).Conclusion:Modified Buyang Huanwu tang combined with diosmin has a significant curative effect in treating chronic venous insufficiency of lower limbs,which can effectively relieve clinical symptoms and inflammatory responses.

关 键 词：下肢慢性静脉功能不全 加减补阳还五汤 地奥司明 炎症因子 

分 类 号：R543.6[医药卫生—心血管疾病]