逍遥舒坤汤加味联合阿奇霉素治疗盆腔炎性疾病后遗症临床研究  

Clinical Study on Modified Xiaoyao Shukun Tang Combined with Azithromycin for Sequelae of Pelvic Inflammatory Disease

作　　者：孙吉飞 陈芸 朱文敏 SUN Jifei;CHEN Yun;ZHU Wenmin

机构地区：[1]德清县中医院妇产科,浙江德清313200 [2]湖州市妇幼保健院妇产科,浙江湖州313000

出　　处：《新中医》2022年第2期106-109,共4页New Chinese Medicine

摘　　要：目的:观察逍遥舒坤汤加味联合阿奇霉素治疗盆腔炎性疾病后遗症(SPID)的临床疗效。方法:选取84例SPID患者,按随机数字表法分为观察组和对照组,每组42例。对照组给予阿奇霉素治疗,观察组在对照组基础上给予逍遥舒坤汤加味治疗,2组均治疗1个月。比较2组临床疗效,观察2组治疗前后盆腔包块直径、T细胞亚群水平、炎症因子水平、红细胞比容(HCT)、红细胞沉降率(ESR)的变化。结果:观察组总有效率为97.62%,高于对照组的83.33%(P<0.05)。治疗后,观察组盆腔包块直径小于对照组(P<0.05),观察组盆腔包块直径治疗前后差值大于对照组(P<0.05)。治疗后,2组血清CD4^(+)、白细胞介素-6 (IL-6)、自然杀伤细胞(NK细胞)水平均较治疗前升高(P<0.05),CD8^(+)、肿瘤坏死因子-α(TNF-α)、HCT、ESR水平均较治疗前降低(P<0.05);观察组CD4^(+)、IL-6、NK细胞水平均高于对照组(P<0.05),CD8^(+)、TNF-α、HCT、ESR水平均低于对照组(P<0.05)。结论:逍遥舒坤汤加味联合阿奇霉素治疗SPID可提高临床疗效,有效缩小盆腔包块,增强机体免疫力,调节炎症因子水平及HCT、ESR。Objective:To observe the clinical effect of modified Xiaoyao Shukun tang combined with azithromycin for sequelae of pelvic inflammatory disease(SPID).Methods:A total of 84 cases of SPID patients were selected and divided into the observation group and the control group according to the random number table method,with 42 cases in each group.The control group was treated with azithromycin,and the observation group was additionally treated with modified Xiaoyao Shukun tang based on the treatment of the control group.Both groups were treated for one month.The clinical effects in the two groups were compared.Before and after treatment,the changes in diameters of pelvic mass,levels of T cell subsets,levels of inflammatory factors,hematocrit(HCT) and erythrocyte sedimentation rate(ESR) in the two groups were observed.Results:The total effective rate was 97.62% in the observation group,higher than that of 83.33% in the control group(P<0.05).After treatment,the diameter of pelvic mass in the observation group was smaller than that in the control group(P<0.05),and the difference of diamter of pelvic mass before and after treatment in the observation group was bigger than that in the control group(P<0.05).After treatment,the levels of CD4^(+),interleukin-6(IL-6) and natural killer(NK) cells in the two groups in serum were increased when compared with those before treatment(P<0.05),and the levels of CD8^(+),tumor necrosis factor-α(TNF-α),HCT and ESR were decreased(P<0.05);the levels of CD4^(+),IL-6 and NK cells in the observation group were higher than those in the control group(P<0.05),and levels of CD8^(+),TNF-α,HCT and ESR were lower(P<0.05).Conclusion:Modified Xiaoyao Shukun tang combined with azithromycin for SPID can improve curative effect,effectively reduce pelvic mass,enhance immunity of the body and regulate levels of inflammatory factors,HCT and ESR.

关 键 词：盆腔炎性疾病后遗症 逍遥舒坤汤 盆腔包块直径 T细胞亚群 炎症因子 红细胞比容 红细胞沉降率 

分 类 号：R711.33[医药卫生—妇产科学]