苦参凝胶联合氟康唑及微波治疗霉菌性阴道炎临床研究  

Clinical Study of Kushen Gel Combined with Microwave and Fluconazole on Mycotic Vaginitis

作　　者：马利文 徐小慧 MA Liwen;XU Xiaohui

机构地区：[1]绍兴市柯桥区妇幼保健院药剂科,浙江绍兴312030 [2]绍兴市柯桥区妇幼保健院妇科,浙江绍兴312030

出　　处：《新中医》2022年第2期114-117,共4页New Chinese Medicine

摘　　要：目的:观察苦参凝胶联合氟康唑及微波治疗霉菌性阴道炎的临床效果。方法:选取霉菌性阴道炎患者60例,按照随机数字表法分为对照组与观察组各30例。对照组给予氟康唑及微波治疗,观察组在对照组的基础上加用苦参凝胶治疗。比较2组临床疗效及主要临床症状体征消失时间,比较2组治疗前后灼痛、外阴瘙痒评分,比较2组治疗期间不良反应发生情况及随访3、6个月的复发情况。结果:治疗后,观察组总有效率为96.67%,对照组为73.33%,2组比较,差异有统计学意义(P<0.05)。治疗后,观察组外阴瘙痒消失、白带减少、黏膜充血消失及外阴阴道疼痛消失时间均明显短于对照组(P<0.05)。治疗前,2组灼痛、外阴瘙痒评分比较,差异无统计学意义(P>0.05);治疗后,2组灼痛、外阴瘙痒评分均较治疗前降低(P<0.05),且观察组2项评分均低于对照组(P<0.05)。治疗期间,2组均无严重不良反应发生。随访3、6个月,观察组复发率分别为0、3.83%,对照组分别为15.0%、30.0%,2组比较,差异均有统计学意义(P<0.05)。结论:苦参凝胶联合氟康唑及微波治疗霉菌性阴道炎能提高临床疗效,有效缓解患者临床症状及体征,加速疾病康复,降低复发率,且无明显不良反应。Objective:To observe the clinical effect of the therapy of Kushen gel combined with microwave and fluconazole on mycotic vaginitis.Methods:A total of 60 patients with mycotic vaginitis were selected and divided into the control group and the observation group according to the random number table method,with 30 cases in each group.The control group was treated with fluconazole and microwave;the observation group was additionally treated with Kushen gel based on the treatment of the control group.The clinical effects and disappearance time of main clinical symptoms and signs in the two groups were compared.Before and after treatment,the scores of burning pain and itching of the vulva in the two groups were compared.During treatment,the incidences of adverse reactions in the two groups were compared.After three and six months of follow-up,the recurrences in the two groups were compared.Results:The total effective rate was96.67% in the observation group and 73.33% in the control group,the difference being significant(P<0.05).After treatment,the time of disappearance of itching of the vulva,mucosal congestion and pain in vulva vaginal and reduction of white vaginal discharge in the observation group was significantly shorter than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of burning pain and itching of the vulva between the two groups(P>0.05);after treatment,the scores of burning pain and itching of the vulva in the two groups were decreased when compared with those before treatment(P<0.05),and the above two scores in the observation group were lower than those in the control group(P<0.05).During treatment,no serious adverse reactions were found in both groups.After three and six months of follow-up,the recurrence rates were 0 and 3.83% in the observation group,and were 15.0% and 30.0% in the study group,differences being significant(P<0.05).Conclusion:The therapy of Kushen gel assisting microwave and fluconazole for mycotic vaginitis

关 键 词：霉菌性阴道炎 苦参凝胶 微波疗法 氟康唑 

分 类 号：R711.31[医药卫生—妇产科学]