补肾活血方对多囊卵巢综合征促排卵患者卵泡发育及妊娠的影响  

Effect of Bushen Huoxue Prescription on Follicular Development and Pregnancy in Patients with Polycystic Ovary Syndrome

作　　者：杨岳 万凌屹[1] 丁彩飞[1] YANG Yue;WAN Lngyi;DING Caifei

机构地区：[1]浙江省中西医结合医院(杭州市红十字会医院),浙江杭州310003

出　　处：《新中医》2022年第2期121-125,共5页New Chinese Medicine

基　　金：浙江省中医药管理局A类项目(2018ZA096);杭州市科技计划项目(20191203B131)。

摘　　要：目的:研究补肾活血方与促排卵药物联合使用对肾虚血瘀型多囊卵巢综合征患者血清雌二醇激素(E_(2))、子宫内膜厚度、血清抗缪勒氏激素(AMH)以及排卵率、受孕率的影响。方法:将符合纳入标准的肾虚血瘀型多囊卵巢综合征患者78例随机分成2组各39例。对照组予克罗米芬并在人绒毛膜促性腺激素(HCG)注射日注射HCG 5000~10000 U;联合用药组在对照组用药的基础上加用补肾活血方治疗。2组均治疗3个月经周期评价疗效。治疗前后检测血清E_(2)、AMH水平并测量HCG注射日子宫内膜厚度,随访并统计入选病例最终的排卵率、受孕率,对收集的数据进行综合分析。结果:治疗后,2组血清E_(2)分别与治疗前比较,差异均无统计学意义(P>0.05),2组血清E_(2)比较,差异无统计学意义(P>0.05)。治疗后,注射HCG当天血清E_(2)均高于注射前,且联合用药组高于对照组,差异均有统计学意义(P<0.01)。治疗后HCG注射日子宫内膜厚度联合用药组(9.37±3.04)mm,对照组(6.60±2.19)mm,2组比较,差异有统计学意义(P<0.01)。治疗后,2组血清AMH分别与治疗前比较,差异均无统计学意义(P>0.05);治疗后,联合用药组AMH低于对照组,差异有统计学意义(P<0.05)。治疗后,联合用药组排卵率及受孕率分别与对照组比较,差异均有统计学意义(P<0.05),联合用药组优于对照组。结论:补肾活血方可以有效提高肾虚血瘀型多囊卵巢综合征患者HCG注射日E_(2)水平、子宫内膜厚度,从而提高排卵率,改善受孕率。Objective:To study the effect of the therapy of Bushen Huoxue prescription combined with ovulation induction medicines on serum estradiol(E_(2)),endometrial thickness,serum anti-mullerian hormone(AMH),and rates of ovulation and pregnancy in patients with polycystic ovary syndrome of kidney deficiency and blood stasis type.Methods:A total of 78 polycystic ovary syndrome patients who met the inclusion criteria were randomly divided into two groups,with39 cases in each group.The control group was treated with clomiphene and 5000-10000 U of HCG was injected on the day of HCG injection;the combined administration group was additionally treated with Bushen Huoxue tang based on the treatment of the control group.Both groups were treated for three menstrual cycles,and the curative effects were evaluated after treatment.Serum levels of E_(2) and AMH before and after treatment were detected,and endometrial thickness on HCG injection day was measured.The final rates of ovulation and pregnancy of selected cases were followed up and counted,and the collected data were comprehensively analyzed.Results:Compared with the same group,there was no significant difference being found in the comparison of serum E_(2) before and after treatment(P>0.05),and after treatment,there was no significant difference being found in the comparison of serum E_(2) between the two groups(P>0.05).After treatment,the serum E_(2) levels in the two groups on the day of HCG injection were higher than those before injection,and the above level in the combined administration group was higher than that in the control group,differences being significant(P<0.01).After treatment,the endometrial thickness on the day of HCG injection was(9.37±3.04)mm in the combined administration group,and(6.60±2.19)mm in the control group,the difference being significant(P<0.01).Compared with the same group,there was no significant difference being found in the comparison of serum AMH before and after treatment(P>0.05);after treatment,the level of AMH in the combined adminis

关 键 词：多囊卵巢综合征 补肾活血方 排卵率 受孕率 

分 类 号：R711.75[医药卫生—妇产科学]