腹腔镜袖状胃切除术对肥胖2型糖尿病患者血糖的影响及与GLP-1/DPP-4通路关系的研究进展  

Research progress of the relationship between the effect of laparoscopic sleeve gastrectomy on blood glucose and GLP-1/DPP-4 pathway in obese patients with type 2 diabetes mellitus

作　　者：马永斌 买买提·依斯热依力 艾克拜尔·艾力[1,2,3] Ma Yongbin;Maimaiti Yisireyili;Aikebaier Aili(Department of Minimally Invasive Surgery,Hernia and Abdominal Wall Surgery,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China;Graduate School of Medicine,Xinjiang Medical University,Urumqi 830054,China;Research Institute of General and Minimally Invasive Surgery of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院微创、疝和腹壁外科,乌鲁木齐830001 [2]新疆医科大学研究生学院,乌鲁木齐830054 [3]新疆维吾尔自治区普外微创研究所,乌鲁木齐830001

出　　处：《中国医师杂志》2022年第1期153-156,共4页Journal of Chinese Physician

基　　金：国家自然科学基金(82060166);新疆维吾尔自治区引进高层次人才天池百人计划项目(201939)。

摘　　要：肥胖症与2型糖尿病(T2DM)都是目前发病率较高的代谢性疾病,两者之间有明确的相关性,减重手术是治疗肥胖症及T2DM的重要外科手段,但关于减重手术对T2DM的影响机制目前尚未明确。减重手术后对胰高血糖素样肽-1(GLP-1)分泌水平产生了一定影响,GLP-1的分泌可以延缓胃排空、增加饱腹感、改善胰岛素抵抗(IR)、促进β细胞胰岛素释放、抑制胰高血糖素合成与分泌、改善胰腺β细胞功能,这些变化均有助于血糖的控制,因此本文就腹腔镜袖状胃切除术(LSG)对肥胖T2DM患者血糖的影响及与GLP-1/DPP-4通路的关系进行总结叙述。Obesity and type 2 diabetes(T2DM)are all the metabolic diseases with high incidence rate.There is a clear correlation between the them.Weight-loss surgery is the important treatment of surgical method for obesity and T2DM.However,the mechanism of T2DM for weight loss surgery is not yet clear.The secretion level of glucagon like peptide-1(GLP-1)was affected after weight loss surgery.The secretion of GLP-1 can delay gastric emptying,increase satiety,improve insulin resistance(IR)and promoteβinsulin release,inhibition of glucagon synthesis and secretion,and improvement of pancreatic functionβcell function.All of these changes were conducive to glycemic control.Therefore,this paper aims to summarize and describe the relationship between the effect of laparoscopic sleeve gastrectomy(LSG)on blood glucose and GLP-1/dipeptidyl peptidase-4(DPP-4)pathway in obese T2DM patients.

关 键 词：腹腔镜袖状胃切除术 胰岛素释放 减重手术 T2DM 肥胖2型糖尿病 外科手段 胰高血糖素 肥胖症 

分 类 号：R656.61[医药卫生—外科学]