Overview of SARS-CoV-2 genome-encoded proteins  

作　　者：Chongzhi Bai Qiming Zhong George Fu Gao 

机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology&Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China [2]Central Laboratory,Shanxi Province Hospital of Traditional Chinese Medicine,Taiyuan 030012,China [3]Shanxi Academy of Advanced Research and Innovation,Taiyuan 030032,China

出　　处：《Science China(Life Sciences)》2022年第2期280-294,共15页中国科学（生命科学英文版）

摘　　要：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread rapidly throughout the world.SARS-CoV-2 is an enveloped,plus-stranded RNA virus with a single-stranded RNA genome of approximately 30,000 nucleotides.The SARS-CoV-2 genome encodes 29 proteins,including 16 nonstructural,4 structural and 9 accessory proteins.To date,over 1,228 experimental structures of SARS-CoV-2 proteins have been deposited in the Protein Data Bank(PDB),including 16 protein structures,two functional domain structures of nucleocapsid(N)protein,and scores of complexes.Overall,they exhibit high similarity to SARS-CoV proteins.Here,we summarize the progress of structural and functional research on SARS-CoV-2 proteins.These studies provide structural and functional insights into proteins of SARS-CoV-2,and further elucidate the daedal relationship between different components at the atomic level in the viral life cycle,including attachment to the host cell,viral genome replication and transcription,genome packaging and assembly,and virus release.It is important to understand the structural and functional properties of SARS-CoV-2 proteins as it will facilitate the development of anti-CoV drugs and vaccines to prevent and control the current SARS-CoV-2 pandemic.

关 键 词：SARS-CoV-2 CORONAVIRUS structural and functional characterization biological impact structure and function-based drug discovery 

分 类 号：Q78[生物学—分子生物学]