颈部淋巴结内注射变应原特异性免疫治疗儿童变应性鼻炎的临床研究  

Clinical study of cervical intralymphatic immunotherapy for allergic rhinitis in children

作　　者：王凯[1] 熊宇 秦扬 于青青[1] 唐隽[1,2] WANG Kai;XIONG Yu;QIN Yang;YU Qingqing;TANG Jun(Department of Otolaryngology Head and Neck Surgery,Foshan First People’s Hospital,Foshan 528000,China;Zhu hai Campus of Zunyi Medical University,Zhuhai 519041,China)

机构地区：[1]佛山市第一人民医院耳鼻咽喉头颈外科,广东佛山528000 [2]遵义医科大学珠海校区,广东珠海519041

出　　处：《中国耳鼻咽喉颅底外科杂志》2022年第1期28-32,共5页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：国家自然科学基金(82101201);广东省科技厅科技计划(2016A020215006)。

摘　　要：目的探究颈部淋巴结内注射变应原特异性免疫治疗(ICLIT)儿童变应性鼻炎(AR)的疗效及安全性。方法回顾性研究24例儿童AR行ICLIT治疗的临床资料,观察患儿基线水平及治疗后1年鼻部症状评分、眼部症状评分、药物评分以及治疗过程中发生不良反应情况,探讨其疗效及安全性。结果24例AR患儿基线水平鼻部总症状评分为(6.00±2.13)分,眼部总症状评分为(3.29±2.12)分,药物评分为(2.67±1.17)分;行ICLIT治疗后1年鼻部总症状评分为(2.96±2.48)分,眼部症状评分为(1.88±1.26)分,药物评分为(1.25±1.19)分;较基线水平明显降低,差异均具有统计学意义(P均<0.01)。ICLIT治疗后1年总有效率为75%。24例AR患儿治疗过程中及随访1年仅2例发生轻微局部不良反应,均未发生全身不良反应。结论ICLIT能显著缓解AR患儿的过敏症状,治疗有效且安全性高,并极大程度地缩短免疫治疗周期。Objective To investigate the efficacy and safety of cervical intralymphatic immunotherapy(CILIT)in children with allergic rhinitis(AR).Methods Clinical data of 24 AR children treated with CILIT were studied retrospectively.The nasal symptom score,ocular symptom score,drug score at baseline and one year after CILIT,as well as adverse reactions during treatment were observed and recorded to explore the efficacy and safety of CILIT.Results The total nasal symptom score,ocular symptom score,and drug score at the baseline were(6.00±2.13),(3.29±2.12)and(2.67±1.17)respectively,while those at one year after CILIT were(2.96±2.48),(1.88±1.26),and(1.25±1.19)The differences between the baseline levels and those at one year after CILIT were all statistically significant(all P<0.01).The total effective rate at one year after CILIT was 75%.During the treatment and follow-up period,only 2 of the 24 children had light local adverse reactions without systemic adverse reactions.Conclusion With good effect and safety,CILIT can significantly alleviate the allergic symptoms of AR in children and greatly shorten the immunotherapy cycle.

关 键 词：变应性鼻炎 儿童 变应原 免疫治疗 疗效 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]