2008-2019年广东省HIV/AIDS病例随访检测时间趋势及影响因素  

Trend and associated factors of follow-up and CD4;T cell testing among HIV/AIDS cases in Guangdong Province from 2008 to 2019

作　　者：刘珺[1] 付笑冰[1] 杨放[1] 宋铁[1] 谢仕兰 黎健荣 刘优招 李艳[1] Liu Jun;Fu Xiao-bing;Yang Fang;Song Tie;Xie Shi-lan;Li Jian-rong;Liu You-zhao;Li Yan(Department for HIV/AIDS Control and Prevention,Guangdong Center for Disease Control and Prevention,Guangzhou 511430,China)

机构地区：[1]广东省疾病预防控制中心艾滋病预防控制所,广州511430

出　　处：《中华疾病控制杂志》2022年第2期182-187,205,共7页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81703282)。

摘　　要：目的分析2008-2019年广东省新报告HIV/AIDS病例随访检测随时间变化趋势及相关影响因素。方法通过AIDS综合防治信息系统中历年的报告卡以及随访数据库,采用Joinpoint回归分析模型了解HIV感染者随访检测指标的年度变化情况,用Logistic回归分析模型分析相关影响因素。结果 2012年为新报告HIV/AIDS病例随访与CD4^(+)T淋巴细胞检测比例趋势变化转折点,2008-2012年间呈快速上升趋势(β=0.3,P<0.001),2012-2019年呈小幅上升趋势;不同地区、不同年龄组的随访检测比例随时间变化的趋势不同。控制其他因素后,发现时间、地区、社会人口学特征、传播途径、发现途径及流动情况,为新报告HIV/AIDS病例完成随访检测的影响因素。结论 2008―2019年广东省AIDS感染者和病人随访管理工作取得了显著进展,但2013年后随访管理工作进展较缓慢。非珠三角地区、高年龄组人群应引起关注。下一步应因地制宜,根据人群特征制定有针对性的工作策略,进一步加强各随访单位的业务能力,做好异地流动的转介工作。Objective To assess the trend and the associated factors of follow-up and CD4;T cell testing(CD4 testing) among HIV/AIDS cases in Guangdong Province from 2008 to 2019. Methods The historical databases were downloaded from the AIDS Comprehensive Prevention and Control Information System. The Joinpoint regression model was used to assess the annual percentage changes in the follow-up and CD4 testing status, and Logistic regression was used to analyze relevant influencing factors. Results The year 2012 was a Joinpoint in the trend of follow-up and CD4 testing rate, with a significant rapid increase from 2008 to 2012(β=0.3, P<0.001), while the speed slowed down after 2012;disequilibrium change of trends over time can be observed among regions as well as age groups. The completion rate of follow-up and CD4 testing can be influenced by different time periods of discovery, regions, sociodemographic characteristics, routes of transmission, routes of discovery, and mobility, after controlling for other factors. Conclusion Significant progress has been made in the follow-up management of HIV infected persons in Guangdong Province from 2008 to 2019, but the process slowed down after 2013. More attention should pay to the patients in non-Pearl River Delta regions and older age groups. Next step, develop targeted strategies which tailored to local conditions and population characteristics, improve capabilities of each follow-up unit, and to do a good job of referrals for off-site mobility.

关 键 词：AIDS 随访 CD4 T淋巴细胞检测 流动 趋势 

分 类 号：R183[医药卫生—流行病学]