生命早期1000天绿地暴露与幼儿睡眠关系队列研究  

The relationship between residential greenness in the first 1 000 days of life and sleep in toddlers: a cohort study

作　　者：吴输 谢路勤 陈宇靖 吴生池 静进[1] 董光辉[2] 林力孜 蔡莉[1] WU Shu;XIE Lu-qin;CHEN Yu-jing;WU Sheng-chi;JING Jin;DONG Guang-hui;LIN Li-zi;CAI Li(Department of Maternal and Child Health,School of Public Health,Sun Yat-sen University,Guangzhou 510080,China;Department of Occupational Health and Environmental Health,School of Public Health,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学公共卫生学院妇幼卫生学系,广州510080 [2]中山大学公共卫生学院劳动卫生与环境卫生学系,广州510080

出　　处：《中华疾病控制杂志》2022年第2期200-205,共6页Chinese Journal of Disease Control & Prevention

基　　金：广东省重点领域研发计划项目(2019B030335001)。

摘　　要：目的探究生命早期1 000 d绿地暴露与2岁幼儿睡眠之间的关联性。方法采用前瞻性队列研究设计,抽取在广州市某区妇幼保健院产检的孕妇,在妊娠20~28周时收集有关的基线信息,并且在生命早期1 000 d,从基于母亲居住地的遥感卫星数据中提取具有不同半径区域(250 m和500 m)的归一化植被指数(normalized difference vegetation index, NDVI)评估生命早期的绿地暴露水平。在幼儿2岁时随访,使用简明婴幼儿睡眠问卷评估其过去1个月的睡眠情况。采用Logistic回归分析模型和多重线性回归模型分别对绿地暴露水平和2岁幼儿睡眠质量、睡眠时间进行关联性分析。结果本研究共纳入410对母子,2岁幼儿每日平均睡眠时间为12.27 h;发生任一睡眠质量问题的比例为39.27%,其中夜醒最高(16.83%),其次是入睡困难(15.61%)和睡眠不规律(13.41%)。Logistic回归分析模型结果显示,未发现生命早期1 000 d的绿地暴露水平与2岁幼儿发生入睡困难、夜醒、睡眠不规律以及以上任一睡眠质量问题有统计学关联(OR=0.77, 95%CI:0.39~1.54,P=0.465;OR=1.30, 95%CI:0.66~2.55,P=0.453;OR=0.87, 95%CI=0.40~1.88,P=0.714;OR=1.21, 95%CI=0.72~2.03,P=0.464)。多重线性回归分析结果显示,未发现生命早期的绿地暴露与2岁幼儿的夜间、日间以及总睡眠时间具有统计学关联(β±s;=-0.04±0.11,P=0.715;β±s;=-0.01±0.08,P=0.957;β±s;=-0.04±0.12,P=0.726)。结论未能发现生命早期1 000 d的绿地暴露和2岁幼儿睡眠质量问题以及睡眠时间有关。Objective To explore the association between residential greenness in the first 1 000 days of life and sleep problems in 2-year toddlers. Methods A prospective cohort study was conducted, from which we selected pregnant women who underwent prenatal examination in a Maternal and Child Health Hospital in Guangzhou. We have collected baseline information at 20-28 weeks of pregnancy. We also calculated normalized difference vegetation index(NDVI) with different buffers(250 m and 500 m) from remote satellite data based on maternal residential addresses to assess the level of residential greenness in the first 1 000 days of life. During the follow-up visits, we collected sleep outcomes during the last months of 2-year toddlers using the Chinese version of the brief infant sleep questionnaire. Logistic regression model and multiple linear regression model were performed to evaluate the association of residential greenness with sleep quality and sleep time, respectively. Results A total of 410 mother-toddler pairs were included, and the average daily sleep time of 2-year toddlers was 12.27 hours. The proportion of sleep quality problem was 39.27%, among which the highest was nocturnal awaking(16.83%), followed by difficulty to fall asleep(15.61%) and irregular sleep(13.41%). In the analyses of Logistic regression, the results indicated null associations of residential greenness in the first 1 000 days of life with the occurrence of difficulty to fall asleep, nocturnal awaking, irregular sleep, or any of the above sleep quality problems in 2-year toddlers(OR=0.77, 95% CI=0.39-1.54, P=0.465;OR=1.30, 95% CI=0.66-2.55, P=0.453;OR=0.87, 95% CI=0.40-1.88, P=0.714;OR=1.21, 95% CI=0.72-2.03, P=0.464). In the analyses of multiple linear regressions, the results indicated null associations between greenness exposure and sleep time at night, sleep time during daytime, and total sleep time in two-year-old toddlers(β±SE=-0.04±0.11, P=0.715;β±SE=-0.01±0.08, P=0.957;β±SE=-0.04±0.12, P=0.726). Conclusion No significant associat

关 键 词：幼儿 睡眠 绿地暴露 生命早期 

分 类 号：R174[医药卫生—妇幼卫生保健] R12[医药卫生—公共卫生与预防医学]