五子四妙加减方联合舍曲林治疗肾虚湿热型早泄临床观察  

Clinical Observation on Modified Wuzi Simiao Prescription Combined with Sertraline in Treating Premature Ejaculation of Kidney Deficiency and Damp-heat Type

作　　者：何珊 李嘉林 林灿彬 陈铭[3] HE Shan;LI Jia-Lin;LIN Can-Bin;CHEN Min(The First Clinical Medical School of Guangzhou Uuiverisity of Chinese Medicine,Guanngzhou 510405 Guangdong,China;Panyu Hospital of Chinese Medicine,Guangzhou 511400 Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]广州市番禺区中医院,广东广州511400 [3]广州中医药大学第一附属医院,广东广州510405

出　　处：《广州中医药大学学报》2022年第2期289-294,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家卫生健康委医药卫生科技发展中心资助项目(编号:HDSL202001025)。

摘　　要：【目的】探讨五子四妙加减方联合舍曲林治疗肾虚湿热型早泄的临床疗效和安全性。【方法】将96例肾虚湿热型早泄患者随机分为中药对照组、西药对照组和联合治疗组,每组各32例。中药对照组给予五子四妙加减方治疗,西药对照组给予盐酸舍曲林片治疗,联合治疗组给予五子四妙加减方联合盐酸舍曲林片治疗,疗程为4周。观察3组患者治疗前后中医证候评分、中国早泄患者性功能评价量表(CIPE-10)评分和阴道内射精潜伏期(IELT)的变化情况,评价3组患者的总体疗效和安全性。【结果】(1)研究过程中,有12例患者未完成1个疗程治疗而脱落退出,最终共有84例患者纳入统计分析,每组各28例。(2)治疗4周后,中药对照组的总有效率为53.57%(15/28),西药对照组为60.71%(17/28),联合治疗组为85.71%(24/28);组间比较,联合治疗组的总体疗效明显优于中药对照组和西药对照组(P<0.05),而中药对照组与西药对照组比较,差异无统计学意义(P>0.05)。(3)治疗后,3组患者的中医证候评分均较治疗前明显降低(P<0.05),但组间比较,差异均无统计学意义(P>0.05)。(4)治疗后,3组患者的CIPE-10评分均较治疗前明显提高(P<0.05),IELT值均较治疗前明显延长(P<0.05),且联合治疗组的CIPE-10评分较中药对照组和西药对照组均明显提高(P<0.05),IELT值较中药对照组和西药对照组均明显延长(P<0.05),而中药对照组与西药对照组比较,差异均无统计学意义(P>0.05)。(5)治疗过程中,3组患者均无明显的不良反应情况发生。【结论】五子四妙加减方联合盐酸舍曲林治疗肾虚湿热型早泄患者的临床疗效优于单纯西药或中药治疗,能显著延长患者射精控精能力,改善患者肾虚湿热症状,降低盐酸舍曲林副作用,提高患者的生活质量和用药安全性。Objective To investigate the clinical effect and safety of modified Wuzi Simiao Decoction combined with sertraline hydrochloride in treating premature ejaculation of kidney deficiency and damp-heat type. Methods Ninety-six premature ejaculation patients with kidney deficiency damp-heat syndrome were randomly divided into the Chinese medicine(CM)group,western medicine group and combined treatment group,with 32 cases in each group. The CM control group was treated with modified Wuzi Simiao Prescription orally, the western medicine group was treated with sertraline hydrochloride tablets,and the combined treatment group was treated with Wuzi Simiao Prescription combined with sertraline hydrochloride tablets,the course of treatment lasting for 4 weeks.The changes of traditional Chinese medicine(TCM)syndrome scores, Chinese Index of Sexual Function for Premature Ejaculation(CIPE-10)scores and intravaginal ejaculation latency time(IELT)in the three groups were observed before and after treatment. After treatment, the overall efficacy and safety of the three groups were evaluated. Results(1)During the trial, 12 patients dropped out for the failure of completing one course of treatment,and a total of 84 patients were included into the statistical analysis,with 28 patients in each group.(2)After 4 weeks of treatment,the total effective rate was 53.57%(15/28) in the CM group,60.71%(17/28)in the western medicine group and 85.71%(24/28)in the combined treatment group. The intergroup comparison showed that the overall efficacy of the combined treatment group was significantly superior to that of the CM group and the western medicine group(P<0.05),while there was no statistical difference between the CM group and the western medicine group(P>0.05).(3)After treatment,TCM syndrome scores in the 3 groups were significantly lower than those before treatment(P<0.05),but the intergroup comparison showed that there was no statistical significance(P>0.05).(4)After treatment, the CIPE-10 scores and IELT of the 3 groups were significantl

关 键 词：早泄 肾虚湿热 五子四妙加减方 盐酸舍曲林片 阴道内射精潜伏期(IELT) 中国早泄患者性功能评价量表(CIPE-10) 

分 类 号：R277.58[医药卫生—中医学]