硬皮病中西医治疗的研究进展  

Advances in Research on Scleroderma Treated with Traditional Chinese Medicine and Western Medicine

作　　者：吴靖雨 熊文倩 陈琳琦 韩飞[2] WU Jing-Yu;XIONG Wen-Qian;CHEN Lin-Qi;HAN Fei(The Fourth School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310053 Zhejiang,China;Pharmacy School,Jiangxi University of Chinese Medicine,Nanchang 330004 Jiangxi,China;Internal Medicine Dept.of Dermatology,Dermatology Hospital of Jiangxi Province,Nanchang 330000 Jiangxi,China)

机构地区：[1]浙江中医药大学第四临床医学院,浙江杭州310053 [2]江西中医药大学药学院,江西南昌330004 [3]江西省皮肤病专科医院皮肤内科,江西南昌330000

出　　处：《广州中医药大学学报》2022年第2期452-458,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81560659);江西省教育厅科学技术研究项目(编号:GJJ201219);江西中医药大学重点学科青年教师培养计划项目(编号:2017jzzdxk001);江西中医药大学博士科研启动基金(编号:2018WBZR011)。

摘　　要：综述近年来硬皮病的发病机制与中西医治疗方法。硬皮病是一种主要累及皮肤、黏膜组织并以纤维化和硬化为主要特征的结缔组织疾病,自身免疫改变和纤维化是该病的突出特征,其发病机制涉及血管异常、结缔组织异常、免疫改变等。西医治疗硬皮病通常采用药物硝苯地平、泼尼松、波生坦、青霉胺、秋水仙碱、伊洛前列腺素、环磷酰胺、霉酚酸酯等,同时结合光疗。用于治疗硬皮病的中药方有葛根汤、补中益气汤、加味阳和汤、当归四逆汤、皮痹方等,同时可结合中医外治法如熏洗、外用酊剂、中药热敷、针灸、艾灸等,均可取得较好的疗效。有关硬皮病的研究今后需进一步明确发病机制,进而采取有效方式以改善免疫缺陷引起的症状;制定特定器官并发症的精准治疗方案及实施个体化管理将是减少硬皮病并发症和改善预后的有效方式。The recent research progress in the pathogenesis and traditional Chinese medicine and western medicine treatment for scleroderma was reviewed. Scleroderma is a kind of connective tissue disease which mainly involves the skin and mucous tissues,and is characterized by fibrosis and sclerosis. The changes of autoimmunity and fibrosis are the specific pathological features of scleroderma. The pathogenesis of scleroderma is related with the vascular disorders,connective tissue disorders,and immune disorders. The western medicine treatment for scleroderma can be mainly achieved by medication of nifedipine,prednisone,bosentan,penicillamine,colchicine,iloprost,cyclophosphamide,and mycophenolate mofetil,and can be assisted by phototherapy. The traditional Chinese medicine treatment for scleroderma can be through the medication of Gegen Decoction, Buzhong Yiqi Decoction,modified Yanghe Decoction,Danggui Sini Decoction,and Pibi Recipe,and can be combined with the external therapies of steaming and washing,external application of tincture,hot-compressing,acupuncture,and moxibustion,which can bring about satisfactory effect. The future research of scleroderma should focus on the further exploration of pathogenesis,and the screening of effective methods for relieving the symptoms induced by the immunodeficiency. The establishment of precise therapy for the complications of specific organs and the individualized management will be the effective method for reducing complications and improving prognosis.

关 键 词：硬皮病 发病机制 中医疗法 西医疗法 综述 

分 类 号：R593.25[医药卫生—内科学]