抗炎低聚糖的制备及其抗炎机制研究进展  

Research Progress on the Preparation and Anti-inflammatory Mechanism of Oligosaccharides

作　　者：黄嘉欢 张铭儒 罗露香 姜晓琳 杨全 程轩轩 HUANG Jiahuan;ZHANG Mingru;LUO Luxiang;JIANG Xiaolin;YANG Quan;CHENG Xuanxuan(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Key Laboratory of State Administration of Traditional Chinese Medicine for Production&Development of Cantonese Medicinal Materials,Comprehensive Experimental Station of Guangzhou,Chinese Materia Medica,China Agriculture Research System,Guangdong Provincial Research Center on Good Agricultural Practice&Comprehensive Agricultural Development Engineering Technology of Cantonese Medicinal Materials,Guangzhou 510006,China)

机构地区：[1]广东药科大学中药学院,国家中医药管理局岭南药材生产与开发重点研究室,国家中药材产业技术体系广州综合试验站,广东省南药规范化种植与综合开发工程技术研究中心,广东广州510006

出　　处：《食品工业科技》2022年第4期413-419,共7页Science and Technology of Food Industry

基　　金：中央本级重大增减支项目(2060302)。

摘　　要：炎症是机体对各种致炎因素及损伤的一种防御反应,也是许多慢性疾病发生的关键因素。研究表明低聚糖具有抗炎、抗菌、抗氧化和抗癌等多种生理活性。作为新型功能性糖源,低聚糖具有低热量、高溶解度、促进双歧杆菌增殖等特点。本文对近年来具有抗炎活性低聚糖的种类和制备方法进行介绍,并从炎症介质和炎症信号通路两方面对其抗炎机制进行综述,以期为新型抗炎药物开发提供参考。Inflammation is a defensive response of the body to various inflammatory factors and injuries,and it is also a key factor in the occurrence of many chronic diseases.The research shows that oligosaccharides have many physiological activities,such as anti-inflammation,anti-biosis,anti-oxidation and anti-cancer.As a new type of functional sugar source,oligosaccharides have the characteristics of low calories,high solubility and promotion of bifidobacterial proliferation.In this article,the types and preparation methods of oligosaccharides with anti-inflammatory activity in recent years are introduced,and the anti-inflammatory mechanisms are reviewed from two aspects of inflammatory mediators and inflammatory signaling pathways,in order to provide the reference for the development of new anti-inflammatory drugs.

关 键 词：低聚糖 制备方法 抗炎机理 

分 类 号：R151.3[医药卫生—营养与食品卫生学]