纤维蛋白原与前白蛋白比值与肌层浸润性膀胱癌患者临床病理指标及预后的关系  

The Relationship betw een the Ratio of Fibrinogen to Prealbumin and Clinicopathological Indexes and Prognosis of Patients with Muscular Invasive Bladder Cancer

作　　者：陈志刚[1] 王小林[1] 郭海锋[1] 徐海飞[1] 朱金锋 CHEN Zhigang;WANG Xiaolin;GUO Haifeng;XU Haifei;ZHU Jinfeng(Department of Urology,Nantong Tumor Hospital,Nantong,Jiangsu Province,226000 China)

机构地区：[1]南通市肿瘤医院泌尿外科,江苏南通226000

出　　处：《系统医学》2021年第24期33-36,共4页Systems Medicine

摘　　要：目的探讨纤维蛋白原与前白蛋白比值(FPR)与肌层浸润性膀胱癌(MIBC)患者临床病理指标及预后的关系。方法回顾性分析2018年1—9月就诊于南通市肿瘤医院泌尿外科的72例MIBC患者临床资料,绘制受试者工作特征曲线(ROC),明确FPR的最佳截断值,按照获取的最佳截断值,将患者分为低FPR组和高FPR组。对比两组临床病理资料、无进展生存期(PFS)和总生存期(OS)差异。结果根据ROC曲线显示FPR的最佳cut-off值为0.097 7,以其为分界点,将32例高于0.097 7者归为高FPR组,40例低于0.097 7者归为低FPR组;高FPR组G3分级占比为46.88%、淋巴结转移占比为15.63%,高于低FPR组的20.00%、0.00%,差异有统计学意义(χ^(2)=5.906、4.516,P=0.015、0.034);两组年龄、性别、TNM分期、糖尿病病史、高血压病史比较,差异无统计学意义(P>0.05);72例患者均实施3年随访,其中生存50例(69.44%),死亡22例(30.56%)。高FPR组PFS为(32.01±2.14)个月,短于低FPR组的(62.52±3.46)个月,差异有统计学意义(t=43.619,P<0.001);高FPR组肿瘤进展率为21.88%(7/32),低于低FPR组的45.00%(18/40),差异有统计学意义(χ^(2)=4.194,P=0.041);高FPR组OS短于低FPR组,差异有统计学意义(P<0.05)。结论 FPR与MIBC患者临床病理特征和预后密切相关,可作为评估患者预后的重要指标。Objective To investigate the relationship between the ratio of fibrinogen to prealbumin(FPR) and the clinicopathological indicators and prognosis of patients with myometrial invasive bladder cancer(MIBC). Methods The clinical data of 72 MIBC patients who were admitted to the Department of Urology, Nantong Tumor Hospital from January to September 2018 were retrospectively analyzed. Draw the receiver operating characteristic curve(ROC) to clarify the best cut-off value of FPR. According to the best cut-off value obtained, patients were divided into low FPR group and high FPR group. The differences in clinicopathological data, progression-free survival(PFS) and overall survival(OS) between the two groups were compared. Results According to the ROC curve, the best cut-off value of FPR was 0.097 7, which was the cut-off point. Thirty-two cases with higher than 0.097 7 were classified as high FPR group, and 40 cases with lower than 0.0977 were classified as low FPR group. The proportion of G3 grade in the high FPR group was 46.88%, and the proportion of lymph node metastasis was 15.63%, which was higher than 20.00% and 0.00% in the low FPR group. The difference was statistically significant(χ^(2)=5.906, 4.516, P=0.015, 0.034). There was no statistically significant difference in age, gender, TNM stage, and diabetes history, history of hypertension between the two groups(P>0.05). All 72 patients were followed up for 3 years, of which 50 cases(69.44%) survived and 22 cases(30.56%) died. The PFS of the high FPR group was(32.01±2.14) months, which was shorter than the(62.52±3.46) months of the low FPR group, and the difference was statistically significant(t =43.619, P <0.001). The tumor progression rate in the high FPR group was 21.88%(7/32), which was lower than 45.00%(18/40) in the low FPR group. The difference was statistically significant(χ^(2)=4.194, P=0.041). The OS of the high FPR group was shorter than that of the low FPR group, and the difference was statistically significant(P<0.05). Conclusion FPR is closel

关 键 词：MIBC 纤维蛋白原与前白蛋白比值 预后 临床病理指标 

分 类 号：R59[医药卫生—内科学]