氨氯地平阿托伐他汀钙片治疗高血压合并冠心病的临床效果分析  

Analysis of the Clinical Effect of Amlodipine and Atorvastatin Calcium Tablets in the Treatment of Hypertension Complicated with Coronary Heart Disease

作　　者：吴静[1] 周雷 WU Jing;ZHOU Lei(Department of Cardiology,Ganyu District People's Hospital,Lianyungang,Jiangsu Province,222100 China)

机构地区：[1]江苏省连云港市赣榆区人民医院心内科,江苏连云港222100

出　　处：《系统医学》2021年第24期97-100,共4页Systems Medicine

摘　　要：目的探析高血压合并冠心病患者接受氨氯地平阿托伐他汀钙片治疗的临床效果。方法选取2017年1月-2019年12月期间该科室收治的84例高血压合并冠心病患者进行临床研究,结合不同诊治方案,以数字表法实施临床分组,对照组(42例)、观察组(42例)分别给予硝苯地平缓释片与氨氯地平阿托伐他汀钙片治疗,关注患者血压血脂改善情况;评估临床疗效差异;观察患者治疗后血管内皮细胞功能及C反应蛋白水平。结果观察组诊治后收缩压(124.68±4.82)mmHg及舒张压(80.28±4.95)mmHg均较对照组低,差异有统计学意义(t=7.925、7.440,P<0.05);观察组TC、TG、LDL-C改善情况更优,差异有统计学意义(t=4.646、4.450、5.517,P<0.05);观察组总有效率高达88.10%,高于对照组,差异有统计学意义(χ^(2)=4.525,P<0.05);观察组血管内皮素、一氧化氮、反应蛋白较对照组相比,差异有统计学意义(P<0.05)。结论高血压合并冠心病患者接受氨氯地平阿托伐他汀钙片治疗和硝苯地平缓释片治疗相比,稳定控制了患者的血压血脂情况,炎症反应较轻,血管内皮功能损伤更小。Objective To analyze the clinical effect of amlodipine and atorvastatin calcium tablets in patients with hypertension and coronary heart disease. Methods A total of 84 patients with hypertension and coronary heart disease admitted to the department from January 2017 to December 2019 were selected for clinical research, combined with different diagnosis and treatment plans, and clinical grouping was implemented by digital table method. The control group(42 cases) and the observation group(42 cases) were treated with nifedipine sustained-release tablets and amlodipine atorvastatin calcium tablets, respectively, and concerned about the improvement of blood pressure and blood lipids of the patients. Assessed differences in clinical efficacy. Observed the function of vascular endothelial cells and the level of C-reactive protein after treatment. Results The systolic blood pressure(124.68±4.82) mmHg and diastolic blood pressure(80.28±4.95) mmHg of the observation group after diagnosis and treatment were lower than those of the control group, and the difference was statistically significant(t=7.925, 7.440, P<0.05). The improvement of TC, TG,LDL-C in the observation group was better, and the difference was statistically significant(t=4.646, 4.450, 5.517, P<0.05). The total effective rate of the observation group was as high as 88.10%, which was higher than that of the control group, and the difference was statistically significant(χ^(2)=4.525, P<0.05). Compared with the control group, there were statistically significant differences in vascular endothelin, nitric oxide, and reactive protein in the observation group(P<0.05). Conclusion Compared with the treatment of patients with hypertension and coronary heart disease who received amlodipine and atorvastatin calcium tablets, the patients’ blood pressure and blood lipids were stably controlled, the inflammatory reaction was lighter, and the damage of vascular endothelial function was less.

关 键 词：高血压合并冠心病 氨氯地平阿托伐他汀钙片 硝苯地平缓释片 血压血脂 

分 类 号：R4[医药卫生—临床医学]