土家药千足虫草抗胃溃疡作用的实验研究  

Study on the Anti-gastric Ulcer Effect of Arrhenatherum Elatius var. Bulbosum ‘Variegatum’,a Tujia Nationality Medicine

作　　者：蒙湘 彭小欢 许馨怡 谭艳颖 王丽华 黄先菊[1] 董悦 MENG Xiang;PENG Xiaohuan;XU Xinyi;TAN Yanying;WANG Lihua;HUANG Xianju;DONG Yue(School of Pharmacy,South-central University For Nationalities,Wuhan 430074,China;Wuhan Institute of Biological Products Co.,Ltd.Wuhan 430207,China)

机构地区：[1]中南民族大学药学院,湖北武汉430074 [2]武汉生物制品研究所有限责任公司,湖北武汉430207

出　　处：《中国民族民间医药》2022年第3期11-16,共6页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：中南民族大学中央高校基本科研业务费专项资金“基于网络药理的民族药有效性与安全性研究”(CZP20002);湖南省支持企业技术创新发展项目(2021BLB174)。

摘　　要：目的:探究土家药千足虫草多糖提取物对无水乙醇致小鼠胃黏膜急性损伤的保护作用。方法:将检疫合格的小鼠随机分为正常对照组、模型组、阳性对照组、低剂量组、中剂量组、高剂量组,以无水乙醇制作小鼠急性胃溃疡损伤模型,测量黏膜出血条带的长度、宽度,计算出血点数目。结果:千足虫草多糖提取物中剂量(350 mg/kg)能较为有效地预防无水乙醇引起的小鼠急性胃黏膜出血损伤。结论:千足虫草多糖提取物中剂量(350 mg/kg)对小鼠胃黏膜损伤具有一定保护作用。Objective To investigate the protective effect of polysaccharide extract ofArrhenatherum elatius var. bulbosum‘Variegatum’ on acute injury of gastric mucosa caused by anhydrous ethanol in mice.MethodsThe mice were randomly divided into control group, model group, positive control group, low dose group, medium dose group and high dose group.ResultThe medium dose(350 mg/kg) ofArrhenatherum elatius var. bulbosum‘Variegatum’ sinensis polysaccharide extract could effectively prevent acute gastric mucosal bleeding injury caused by anhydrous ethanol in mice.ConclusionThe medium dose(350 mg/kg) ofArrhenatherum elatius var. bulbosum‘Variegatum’ sinensis polysaccharide extract had a protective effect on gastric mucosa injury in mice.

关 键 词：胃黏膜损伤 千足虫草 多糖 溃疡指数 损伤抑制率 

分 类 号：R285.6[医药卫生—中药学]