神经精神性红斑狼疮的免疫学机制及其常用动物模型研究进展  

Research progress of immunological pathogenesis and commonly used animal models of neuropsychiatric systemic lupus erythematosus

作　　者：燕红梅 巫燕琴 郑晓杰 董光富[4] YAN Hong-mei;WU Yan-Qin;ZHENG Xiao-jie;DONG Guang-fu(School of Medicine,South China University of Technology,Guangzhou 510006,China;Southern Medical University,Guangzhou 510515,China;School of Medicine,Shantou University,Shantou 515041,China;Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China)

机构地区：[1]华南理工大学医学院,广东广州510006 [2]南方医科大学,广东广州510515 [3]汕头大学医学院,广东汕头515041 [4]广东省人民医院,广东省医学科学院,广东广州510080

出　　处：《中国病理生理杂志》2022年第2期333-341,共9页Chinese Journal of Pathophysiology

基　　金：广东省中医药局重点项目(No.20193001);广州市科技计划项目(No.202102080087)。

摘　　要：系统性红斑狼疮(systemic lupus erythematosus,SLE)是以系统性、慢性、复发-缓解交替为特征的自身免疫性疾病典型代表,主要临床特点是血循环可检出大量自身抗体及多器官受损,其中神经精神性红斑狼疮(neuropsychiatric systemic lupus erythematosus,NPSLE)是常见并发症,患病率介于37%~95%之间,仅次于狼疮性肾炎,已成为影响SLE患者预后的主要因素之一[1]。目前NPSLE发病机制仍有很多未明之处,诊断与治疗仍面临很多挑战[2],加强NPSLE发病机制研究意义重大。本文将主要从神经免疫界面受损、免疫效应细胞、炎症因子、致病性自身抗体在NPSLE中发病作用研究进展及NPSLE研究常用动物模型进行综述,为阐明NPSLE发病机制和寻找研究靶点提供参考。Neuropsychiatric systemic lupus erythematosus(NPSLE)is a major complication of systemic lupus erythematosus(SLE)involving the nervous system. It is one of the main risk factors for the prognosis of SLE patients. Although there is still so much that is unknown about the pathogenesis of NPSLE,progress has been made in recent years.This review summarizes the role and mechanism of immune effector cells,inflammatory mediators and pathogenic autoantibodies,and the commonly used animal models in the research of NPSLE pathogenesis.

关 键 词：神经精神性红斑狼疮 神经免疫界面 免疫效应细胞 炎症介质 致病性自身抗体 动物模型 

分 类 号：R593.24[医药卫生—内科学] R363.2[医药卫生—临床医学]