趋化因子及其受体参与癌痛的研究进展  

Research progress of chemokines and their receptors in cancer pain

作　　者：鲁莹 李勃 王蓉 万琪 曾俊伟 LU Ying;LI Bo;WANG Rong;WAN Qi;ZENG Jun-wei(Department of Physiology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学生理学教研室,贵州遵义563000

出　　处：《中国病理生理杂志》2022年第2期364-369,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.31860291);2018年贵州省教育厅创新群体重大研究项目(黔教合KY字[2018]025)。

摘　　要：癌痛是指由于肿瘤压迫神经或者肿瘤直接侵犯组织导致的疼痛,这严重降低了癌症患者的生活质量。大多数癌痛是慢性的,病程3个月以上,疼痛程度通常与肿瘤生长或诊疗情况密切联系。癌痛可以分成伤害感受性疼痛及神经病理性疼痛,前者又区分为躯体痛及内脏痛;后者表现为持续出现痛觉过敏症状,这与外周或中枢神经发生病变有关。目前,关于癌痛的诊治尚缺乏有成效的具体方案。Chemokines bind to its G-protein-coupled receptors on target cells inducing adjacent responding cells to produce directional chemotaxis. Interaction of chemokines and their receptors in dorsal root ganglion neurons,spinal dorsal horn and brain participates in the generation and maintenance of cancer pain in response to noxious stimuli.Chemokines have been suggested as candidates of cancer pain treatment. This article reviews the research progress of chemokines and their receptors involved in cancer pain.

关 键 词：趋化因子 趋化因子受体 癌痛 

分 类 号：R338.2[医药卫生—人体生理学] R363[医药卫生—基础医学]