基于数据挖掘分析郑氏喉科吹药治疗喉风的学术特色  

Analysis of the Academic Characteristics of Zheng’s Laryngology Insufflating Medicinal Powder in Treating Laryngitis Based on Data Mining

作　　者：孙晨 郑日新[2] 屠彦红[2] 宋若会[2] Sun Chen;Zheng Rixin;Tu Yanhong;Song Ruohui(Anhui University of Chinese Medicine,Anhui,Hefei 230001,China.)

机构地区：[1]安徽中医药大学,安徽合肥230001 [2]安徽中医药大学第一附属医院,安徽合肥230031

出　　处：《中国中医急症》2022年第2期198-202,254,共6页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82074501);全国中医学术流派传承工作室(新安医学郑氏喉科流派传承工作室)第二轮建设项目(国中医药人教函〔2019〕62号);郑日新全国名老中医药专家传承工作室建设项目(国中医药人教函〔2018〕134号)。

摘　　要：目的通过数据挖掘的方法,探究郑氏喉科流派运用吹药治疗喉风的治则和用药规律,为临床治疗咽喉危急重症提供决策支持。方法在郑氏喉科代表性医著《重楼玉钥》《重楼玉钥续编》中,选取符合纳入标准的吹药方剂建立数据库,采用频数、关联规则、系统聚类等方法,分析郑氏喉科吹药治疗喉风的用药规律。结果本研究共纳入吹药方剂22首,涉及中药46种。高频使用药物有冰片、硼砂、芒硝、白矾、薄荷、儿茶等。药物的性味分析中,辛味药(36.96%)、甘味药(32.61%)、寒凉药(67.39%)、平性药(18.52%)为主。挖掘得到关联规则12条,2味药7条:“冰片-薄荷”“儿茶-黄柏”“薄荷-黄柏”“冰片-黄柏”。3味药5条:“薄荷-儿茶-黄柏”“冰片-黄柏-儿茶”等。网络链接分析得出,其中强链接配伍有4组,为“冰片-硼砂”“硼砂-芒硝”“冰片-薄荷”和“冰片-芒硝”;中等链接配伍31组;弱链接配伍22组。当距离为21时聚类分析,得到如下4组药物组合。C1:儿茶、黄柏、薄荷、青黛。C2:冰片、雄黄、猪牙皂。C3:僵蚕、硼砂、芒硝。C4:灯芯草、甘草、白矾、寒水石。结论郑氏喉科吹药治疗喉风多选用“清热散邪”“涤痰消肿”类药物,并体现“辛凉养阴”的学术特色,具有紧扣病机、随症施治、快捷效显的特点,值得进一步挖掘研究。Objective:To discuss the characteristics and compatibility of Zheng′s laryngology insufflatingmedi⁃cal powder in treating laryngitis by sorting out the related prescriptions in Chonglou Yuyue and Chonglou Yuyue Sequel.Methods:Prescriptions that met the inclusion criteria to were selected toestablish a database,and meth⁃ods such as frequency,association rules,and clustering were used to analyze the medication rules of Zheng’s laryn⁃gology department for the treatment of laryngitis.Results:A total of 22 prescriptions and 46 medicines were in⁃cluded in this study.Frequently used drugs included Bingpian,Pengsha,Mangxiao,Baifan,Bohe and Ercha.In the analysis of the nature and taste of the drugs,the pungent herbs(36.96%),the sweet herbs(32.61%),the cold herbs(67.39%)and the flat herbs(18.52%)were the main ones.Through mining,12 association rules were obtained:7 for 2 medicines,i.e.,“Bingpian-Bohe”“Ercha-Huangbai”“Bohe-Huangbai”“Bingpian-Huangbai”,etc.;5 for 3 medicines,i.e.,“Bohe-Ercha-Huangbai”“Bingpian-Huangbai-Ercha”,etc.Network link analysis showed that there were 4 groups of strong link compatibility,i.e.,“Bingpian-Pengsha”“Pengsha-Mangxiao”“Bingpian-Bohe”“Bingpian-Mangxiao”;31 groups of medium link compatibility;and 22 groups of weak link compatibility.When the distance was 21,4 drugcombinations were obtained through cluster analysis,i.e.,C1:Ercha,Huangbai,Bohe,Qingdai;C2:Bingpian,Xionghuang,Zhuyazao;C3:Jiangcan,Pengsha,Mangxiao;C4:Dengxincao,Gancao,Baifan,Hanshuishi.Conclusion:Zheng′s laryngology department for treating laryngitis takes“nourishing yin with pun⁃gent and cool-natured drugs”as the treatment principle,and chooses“clearing away heat and relieving stagnation,removing phlegm and reducing swelling”as the treatment method.It has the characteristics of being closely relat⁃ed to the pathogenesis,treating according to the disease,and being quick and effective,which is worthy of further research,promotion and application.

关 键 词：喉风 新安郑氏喉科 吹药 用药规律 数据挖掘 

分 类 号：R276.1[医药卫生—中医五官科学]