清黄饮对HBV相关慢加急性肝衰竭阳黄患者的疗效及预后研究  

Intervention and Prognostic Study of Qinghuang Decoctionon 80 Patients with HBV-related Acute-on-chronic Liver Failure

作　　者：黄人鹤 谢青 闫雪华[1] 陈小勇[1] Huang Renhe;Xie Qing;Yan Xuehua;Chen Xiaoyong(LanzhouSecond Pepole′s Hospital,Gansu,Lanzhou 730046,China.)

机构地区：[1]甘肃省兰州市第二人民医院,甘肃兰州730046

出　　处：《中国中医急症》2022年第2期310-313,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：甘肃省中医药管理局科研课题(GZK-2019-73)。

摘　　要：目的观察清黄饮对乙型肝炎病毒(HBV)相关慢加急性肝衰竭阳黄患者的短期干预作用并探讨其作用机制。方法将80例HBV相关慢加急性肝衰竭患者随机分为对照组与治疗组各40例。对照组予以西医综合治疗,治疗组在对照组的基础上予清黄饮治疗8周,比较两组疗效指标。结果治疗组临床总有效率为80.00%,高于对照组的52.50%;治疗组胆红素消退总有效率为90.00%,高于对照组的72.50%(均P<0.05)。两组治疗后的中医临床症状评分与治疗前比较均降低,且治疗组同期均低于对照组(均P<0.05)。两组治疗后谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBiL)水平均较治疗前下降(均P<0.05);且治疗组TBiL水平低于对照组(P<0.05)。两组治疗后凝血酶原活动度(PTA)水平较治疗前下降(P<0.05)。结论在规范化的西医综合治疗基础上加用清黄饮干预治疗,对HBV相关慢加急性肝衰竭患者短期黄疸消退作用、肝功能及凝血功能改善明显。Objective:To observe the short-term intervention mechanism and to investigate the mechanism of Qinghuang Decoction patients with HBV-related acute-on-chronic liver failure.Methods:A total of 80 cases of HBV-related acute-on-chronic liver failurewere randomly divided into the control group and treatment group,40 cases in each group.The control group was given western medicine comprehensive treatment,and the treatment group was given Qinghuang Decoction for 8 weeks on the basis of the control group.Results:The clinical total effective rate of the treatment group was 80.00%,which was higher than 52.50%of the control group;the total effective rate of bilirubin regression in the treatment group was 90.00%,which was higher than 72.50%of the control group(both P<0.05).The TCM clinical symptom scores of the two groups after treatment were lower than those before treatment,and the treatment group was lower than the control group at the same period(all P<0.05).After treatment,the levels of ALT,AST and TBiL in the two groups were decreased compared with those before treatment(all P<0.05);and the level of TBiL in the treatment group was lower than that in the control group(P<0.05).The levels of PTA in the two groups after treatment were lower than those before treatment(P<0.05).Conclusion:On the basis of standardized western medicine comprehensive treatment,the addition of Qinghuang Decoction can significantly improve the short-term jaundice subsidence,liver function and coagulation function in patients with HBV-related acute-on-chronic liver failure.

关 键 词：HBV相关慢加急性肝衰竭 阳黄 清黄饮 预后研究 

分 类 号：R256.41[医药卫生—中医内科学]