毛细血管内增生性肾小球肾炎伴乙型肝炎病毒抗原沉积患者血清免疫球蛋白变化  

Changes of serum immunoglobulin in patients with endocapillary proliferative glomerulonephritis with hepatitis B virus antigen deposition

作　　者：张莹涛 杨蓉 高娜[1] ZHANG Yingtao;YANG Rong;GAO Na(Department of Nephrology,Yan′an People′s Hospistal,Yan′an 716000,China)

机构地区：[1]延安市人民医院肾内科,陕西延安716000

出　　处：《延安大学学报（医学科学版）》2021年第4期49-52,共4页Journal of Yan'an University:Medical Science Edition

基　　金：2019年陕西省科协企业创新争先青年人才托举计划(20190306)。

摘　　要：目的分析毛细血管内增生性肾小球肾炎(endocapillary proliferative glomerulonephritis,EPGN)合并乙型肝炎病毒(HBV)抗原沉积患者血清免疫球蛋白(immunoglobulin,Ig)变化。方法选取延安市人民医院收治的46例EPGN伴HBV抗原沉积患者为研究组,同期选取延安市人民医院收治的40例单纯肾小球肾炎患者为对照组。比较2组患者血清细胞因子、肝功能、肾功能及Ig含量的差异,采用Pearson相关性分析EPGN伴HBV抗原沉积患者Ig含量与细胞因子、肝功能、肾功能指标的关系。结果研究组血清白细胞介素-12(IL-12)、白细胞介素-10(IL-10)及白细胞介素-6(IL-6)含量较对照组均显著升高(P<0.01)。与对照组比较,研究组总胆红素(TBil)、天门冬氨酸氨基转移酶(AST)及丙氨酸氨基转移酶(ALT)浓度均显著升高(P<0.01)。研究组肾小球滤过率(GFR)较对照组显著降低,血肌酐(Scr)和尿素氮(BUN)浓度较对照组均显著升高(P<0.01)。相比对照组,研究组血清免疫球蛋白M(IgM)、免疫球蛋白A(IgA)及免疫球蛋白G(IgG)含量均显著升高(P<0.01)。经Pearson相关性分析发现,EPGN伴HBV抗原沉积患者IgM、IgA、IgG与GFR均存在负相关关系,与IL-12、IL-10、IL-6、TBil、AST、ALT、Scr、BUN均存在正相关关系(P<0.05)。结论 EPGN伴HBV抗原沉积患者血清Ig含量较高,且与细胞因子、肝肾功能均存在一定关系。Objective To analyze the changes of serum immunoglobulin(Ig) in patients with endocapillary proliferative glomerulonephritis(EPGN) combined with hepatitis B virus(HBV) antigen deposition.Methods 46 EPGN patients with HBV antigen deposition in Yan′an People′s Hospital were selected as study group,and 40 patients with simple glomerulonephritis in Yan′an People′s Hospital were selected as control group.The differences of serum cytokines,liver function,renal function and Ig content in the two groups were compared.Pearson correlation was used to analyze the relationship between Ig content and cytokines,liver function and renal function in EPGN patients with HBV antigen deposition.Results The serum levels of interleukin-12(IL-12),interleukin-10(IL-10) and interleukin-6(IL-6) in the study group were significantly higher than those in the control group(P<0.01).Compared with the control group,the concentrations of total bilirubin(TBil),aspartate aminotransferase(AST)and alanine aminotransferase(ALT) in the study group were significantly increased(P<0.01).The glomerular filtration rate(GFR)of the study group was significantly lower than that of the control group,and the serum creatinine(Scr)and blood urea nitrogen(BUN)concentrations were significantly higher than those of the control group(P<0.01).Compared with the control group,serum immunoglobulin M(IgM),immunoglobulin A(IgA) and immunoglobulin G(IgG) levels in the study group were significantly increased(P<0.01).Pearson correlation analysis showed that IgM,IgA,IgG and GFR of EPGN patients with HBV antigen deposition were negatively correlated,and positively correlated with IL-12,IL-10,IL-6,TBil,AST,ALT,Scr and BUN(P<0.05).Conclusion The content of serum Ig in EPGN patients with HBV antigen deposition was higher,which was correlated with cytokines,liver and kidney functions.

关 键 词：乙型肝炎病毒 毛细血管内增生性肾小球肾炎 免疫球蛋白 细胞因子 肝肾功能 

分 类 号：R692.3[医药卫生—泌尿科学] R512.62[医药卫生—外科学]