血清NGAL、MMP-28在老年急性ST段抬高型心肌梗死患者中的表达及临床意义  

The Expression and Clinical Significance of Serum NGAL and MMP-28 in Elderly Patients with Acute ST-segment Elevation Myocardial Infarction

作　　者：尹莉 赵智丽[2] 李春林[3] YIN Li;ZHAO Zhili;LI Chunlin(Jingxi Medical District,PLA General Hospital,Beijing 100097,China;Department of Cardiovascular Medicine,The First Medical Center of PLA General Hospital,Beijing 100853,China;Health Center,The EighthMedical Center of PLA General Hospital,Beijing 100089,China)

机构地区：[1]解放军总医院京西医疗区,北京100097 [2]解放军总医院第一医学中心心血管内科,北京100853 [3]解放军总医院第八医学中心健康医学科,北京100089

出　　处：《标记免疫分析与临床》2022年第1期1-5,共5页Labeled Immunoassays and Clinical Medicine

基　　金：军队医学科技青年培育计划孵化项目(编号:16QNP036)。

摘　　要：目的探讨血清中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、基质金属蛋白酶-28(MMP-28)在老年急性ST段抬高型心肌梗死(ASTEMI)患者中的表达及临床意义。方法选取2017年1月至2019年1月在我科接受PCI治疗的老年ASTEMI患者150例(观察组),根据患者随访期间有无MACE发生,分为MACE发生组(n=50)和无MACE发生组(n=100)。同期另选我院老年健康体检者100例(对照组)。检测并比较各组血清NGAL、MMP-28水平。应用ROC曲线分析血清NGAL、MMP-28对老年ASTEMI患者预后的预测价值,并以多因素Logistic回归分析影响患者预后的危险因素。结果观察组血清NGAL、MMP-28水平高于对照组,MACE发生组患者血清NGAL、MMP-28水平高于无MACE发生组,差异均具有统计学意义(P<0.05)。Pearson相关性分析示:血清NGAL、MMP-28与LVEF呈负相关,与Gensini评分呈正相关(均P<0.05)。血清NGAL、MMP-28预测老年ASTEMI患者不良预后的曲线下面积为0.837、0.872,灵敏度、特异性分别为(0.786和0.794)、(0.804和0.765)。多因素Logistic回归分析显示,血清NGAL、MMP-28升高是影响老年ASTEMI患者不良预后的独立危险因素(P<0.05)。结论血清NGAL、MMP-28水平与老年ASTEMI患者PCI术后患者预后密切相关,是影响患者预后的重要危险因素,联合检测血清NGAL、MMP-28对老年ASTEMI患者预后评估的有较高预测价值。Objective To investigate the expression and clinical significance of serum neutrophil gelatinase-associated lipocalin(NGAL)and matrix metalloproteinase-28(MMP-28)in elderly patients with acute ST-segment elevation myocardial infarction(ASTEMI).Methods A total of 150 elderly ASTEMI patients(observation group)who received PCI treatment in our department from January,2017 to January,2019 were selected for the study.According to the occurrence of MACE during follow-up period,these patients were divided into the MACE occurrence group(n=50)and MACE-free group(n=100).During the same period,another 100 elderly patients(control group)were selected from physical examination in our hospital.We detected and compared serum NGAL and MMP-28 levels among these groups.The ROC curve was drawn to analyze the predictive value of serum NGAL and MMP-28 on the prognosis of elderly ASTEMI patients.Multivariate logistic regression was applied to analyze the risk factors affecting the prognosis of patients.Results Serum NGAL and MMP-28 levels in the observation group were higher than those in the control group,and serum NGAL and MMP-28 levels in the MACE group were higher than those in the non-MACE group,with significant differences(P<0.05).Pearson correlation analysis showed that serum NGAL and MMP-28 were negatively correlated with LVEF,while positively correlated with Gensini score(P<0.05).The area under the curve of serum NGAL and MMP-28 predicting poor prognosis of elderly ASTEMI patients were 0.837 and 0.872,and the sensitivity and specificity were 0.786/0.794 and 0.804/0.765,respectively.Multivariate logistic regression analysis showed that elevated serum NGAL and MMP-28 were independent risk factors affecting the poor prognosis of elderly patients with ASTEMI(P<0.05).Conclusion Serum NGAL and MMP-28 levels are closely related to the prognosis of elderly patients with ASTEMI after PCI,and are important risk factors affecting the prognosis of patients.The combined detection of these markers has a high predictive value for the progno

关 键 词：中性粒细胞明胶酶相关脂质运载蛋白 基质金属蛋白酶-28 急性ST段抬高型心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]