肝小叶内生物流体力——中医药调治“气血津液”防治肝纤维化研究的一个重要切入点  

Biofluid Mechanics in Hepatic Lobules-a New Research Perspective of Liver Fibrosis Treatment by "Qi, Xue, Jin, and Ye" Theory in Traditional Chinese Medicine

作　　者：武庆娟 吕文良[1] 李娟梅[1] 周文慧[1] WU Qing-juan;LU Wen-liang;LI Juan-mei;ZHOU Wen-hui(Department of Infection,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing(100053))

机构地区：[1]中国中医科学院广安门医院感染疾病科,北京100053

出　　处：《中国中西医结合杂志》2022年第1期101-106,共6页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家重点研发计划“中医药现代化研究”重点专项(No.2018YFC1705700)。

摘　　要：中医药的肝纤维化防治立足于整体观,强调辨证论治,具有良好的临床疗效。结合现代前沿学科深入探索肝纤维化的中医药防治机制,有利于促进肝纤维化临床诊疗水平的提高和学术发展。基于"生物力药理学"理论,从肝小叶内生物流体力与中医药调治"气血津液"防治肝纤维化的关系角度出发,立足于生物-化学-力学-功能耦合机制探索中医药防治肝纤维化的药理机制,是中医学理论与现代前沿科学的有机结合,是将来具有潜力的研究方向。The prevention and treatment of liver fibrosis(LF) by traditional Chinese medicine(TCM) shows favorable clinical efficacy based on the holistic view theory and syndrome differentiated treatment.The mechanism of TCM for preventing and treating LF by combining modern frontline principles is beneficial to promoting the elevation and academic development of LF clinical diagnosis and treatment levels. Based on biomechanopharmacology theory, exploring pharmacological mechanism of TCM in treatment of LF from the relationship between biofluid mechanics in hepatic lobules and "qi, xue, jin, and ye", rooted in based on biological-chemical-mechanical-functional coupling mechanism is an organic combination of TCM theories and modern frontier sciences, which will be a potential research direction in the future.

关 键 词：生物力药理学 生物流体力学 中医药 气血津液 肝纤维化 

分 类 号：R259[医药卫生—中西医结合]