病毒感染后咳嗽发病机制的研究进展  

Progress in the pathogenesis of post-infectious persistent cough

作　　者：李凤英 邓政 Li Fengying;Deng Zheng(Guangzhou Institute of Respiratory Health,State Key Laboratory of Respiratory Disease,National Center for Respiratory Medicine,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]广州医科大学附属第一医院,国家呼吸医学中心,呼吸疾病国家重点实验室,广州呼吸健康研究院,广州510120

出　　处：《中华结核和呼吸杂志》2022年第2期213-217,共5页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金(81970013);广州市科技计划项目(202002030151);广东省钟南山医学基金会(ZNSA-2020003)。

摘　　要：呼吸道病毒感染是急性咳嗽的常见原因。但是在病因清除及发热、鼻塞、流涕等症状缓解后,仍有部分患者存在持续的咳嗽,表明呼吸道病毒可能会介导咳嗽的敏感性增高,导致亚急性或慢性咳嗽的发生。病毒感染后的咳嗽反应是防止病毒从上呼吸道传播到其他部位的保护性策略,但过度咳嗽就成为了一种疾病。本文介绍了呼吸道病毒感染后亚急性或慢性咳嗽发生的病理生理机制,并探讨了相关研究进展。Respiratory viral infection is a common cause of acute cough.After the cause has been cleared and the symptoms such as fever,nasal congestion and runny nose have been relieved,some patients still have persistent cough.These phenomena indicate that respiratory viruses may mediate cough hypersensitivity and lead to the occurrence of sub-acute or chronic cough.Cough response to viral infection is a protective strategy to prevent the spread of the viruses from the upper respiratory tract to other sites,but excessive coughing becomes a disease.In this review,we introduced the research progress in the pathophysiological mechanism of post-viral persistent cough or chronic cough.

关 键 词：呼吸道病毒感染 病理生理机制 慢性咳嗽 呼吸道传播 咳嗽反应 常见原因 发病机制 敏感性 

分 类 号：R441.5[医药卫生—诊断学]