血清钙磷乘积与原发性醛固酮增多症的相关性  

Association between serum calcium-phosphorus product and primary aldosteronism

作　　者：王梦卉[1] 张玮玮[1] 彩丽[1] 骆秦[1] 姚晓光[1] 张智华 荣立伟 李南方[1] WANG Menghui;ZHANG Weiwei;CAI Li;LUO Qin;YAO Xiaoguang;ZHANG Zhihua;RONG Liwei;LI Nanfang(Hypertension Center,People's Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Hypertension Institute,Urumuqi,830001,China)

机构地区：[1]新疆维吾尔自治区人民医院高血压中心新疆高血压研究所,乌鲁木齐830001

出　　处：《临床心血管病杂志》2022年第1期68-72,共5页Journal of Clinical Cardiology

基　　金：新疆维吾尔自治区自然科学基金计划项目(No:2018D01C096)。

摘　　要：目的:探讨血清钙磷乘积与原发性醛固酮增多症(PA)的关系。方法:回顾性分析2010年1月—2013年12月就诊于新疆维吾尔自治区人民医院高血压中心规范进行PA筛查,并完善血清离子测定的803例高血压患者,其中PA患者157例,非PA患者646例。结果:与非PA组比较,PA患者钙磷乘积较低[(2.44±0.42) mmol/L∶(2.61±0.48) mmol/L,P<0.01]。受试者工作特征曲线分析显示钙磷乘积对PA有预测价值,曲线下面积为0.61(95%CI 0.56~0.66,P<0.01),当钙磷乘积≤2.55 mmol/L时筛查PA的敏感性及特异性分别为66.9%及53.4%。Logistic回归分析显示,独立于PA其他典型的或综合性的临床指标,钙磷乘积≤2.55 mmol/L是PA的独立危险因素(OR=2.02,95%CI 1.37~2.99,P<0.01)。结论:钙磷乘积与PA有关,是反映PA患者骨健康问题的综合性指标,对PA的临床诊断有参考价值。Objective: To determine the association between calcium-phosphorus(Ca-P) product and primary aldosteronism(PA). Methods: A retrospective analysis was performed on 803 patients with hypertension who were admitted to the Hypertension Center of The People’s Hospital of Xinjiang Uygur Autonomous Region from January 2010 to December 2013. Among them, 157 patients with hypertension were confirmed PA and 646 patients were non-PA. Results: Compared with non-PA group, PA patients had a lower Ca-P product level[(2.44±0.42) mmol/L vs.(2.61±0.48) mmol/L, P<0.01]. ROC curve analysis showed that Ca-P product level less than 2.55 mmol/L can predict PA, with an area under the curve of 0.61(95%CI0.56-0.66, P<0.01). And the sensitivity and specificity were 66.9% and 53.4%, respectively. Logistic regression analysis showed that the product of calcium and phosphorus≤2.55 mmol/L was an independent risk factor for PA(OR=2.02, 95%CI1.37-2.99, P<0.01), independent of other typical or comprehensive clinical indicators of PA. Conclusion: Decreased Ca-P product is a typical clinical feature in PA patients, which can reflect bone health problems for PA patients and can help clinician screen for PA.

关 键 词：高血压 原发性醛固酮增多症 钙磷乘积 骨健康 

分 类 号：R544.1[医药卫生—心血管疾病]