前列舒通胶囊联合体外冲击波治疗对慢性前列腺炎患者炎性因子和免疫功能的影响  

Effects of qianlieshutong capsule combined with extracorporeal shock wave therapy on inflammatory factors and immune function in patients with chronic prostatitis

作　　者：莫先红 Mo Xianhong(Department of Urinary Surgery,Yingcheng People′s Hospital,Yingcheng 132400,China)

机构地区：[1]应城市人民医院泌尿外科,应城432400

出　　处：《中国医师进修杂志》2022年第1期54-60,共7页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨前列舒通胶囊联合体外冲击波治疗对慢性前列腺炎(CP)患者炎性因子和免疫功能的影响。方法回顾性分析应城市人民医院2019年9月至2020年9月100例CP患者的临床资料。其中,采用体外冲击波治疗50例(对照组),前列舒通胶囊联合体外冲击波治疗50例(观察组)。比较两组治疗前后美国国立卫生院前列腺炎症状指数(NIH-CPSI)、白细胞介素(IL)-6、IL-8、肿瘤坏死因子(TNF)-α、T淋巴细胞亚群、卵磷脂小体(SPL)和前列腺特异抗原(PSA)水平。比较两组不良反应和疗效。结果观察组总有效率明显高于对照组[88.0%(44/50)比70.0%(35/50)],差异有统计学意义(χ^(2)=4.88,P<0.05)。两组治疗前NIH-CPSI各项评分和总分比较差异无统计学意义(P>0.05);观察组治疗后NIH-CPSI疼痛不适、排尿情况、症状影响、生命质量评分和总分明显低于对照组[(4.15±1.04)分比(6.72±1.13)分、(1.23±0.39)分比(1.88±0.48)分、(1.31±0.39)分比(1.91±0.35)分、(1.68±0.34)分比(2.35±0.32)分和(8.37±1.02)分比(12.86±1.33)分],差异有统计学意义(P<0.01)。两组治疗前前列腺液和血清IL-6、IL-8和TNF-α比较差异无统计学意义(P>0.05);观察组治疗后前列腺液和血清IL-6、IL-8和TNF-α均明显低于对照组,差异有统计学意义(P<0.01)。两组治疗前CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)和CD_(4)^(+)/CD_(8)^(+)比较差异无统计学意义(P>0.05);两组治疗后CD_(3)^(+)、CD_(4)^(+)和CD_(8)^(+)比较差异无统计学意义(P>0.05),观察组CD_(4)^(+)/CD_(8)^(+)明显高于对照组(1.48±0.33比1.35±0.28),差异有统计学意义(P<0.05)。两组治疗前SPL和PSA比较差异无统计学意义(P>0.05);观察组治疗后SPL明显高于对照组[(33.25±4.08)μg/L比(20.96±4.13)μg/L],PSA明显低于对照组[(0.81±0.23)μg/L比(0.97±0.29)μg/L],差异有统计学意义(P<0.01)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论前列舒通胶囊联合体外冲击波治疗CP疗效明Objective To investigate the effects of qianlieshutong capsule combined with extracorporeal shock wave therapy on inflammatory factors and immune function in patients with chronic prostatitis(CP).Methods The clinical data of 100 patients with CP in Yingcheng People′s Hospital from September 2019 to September 2020 were retrospectively analyzed.Among them,50 cases were treated with extracorporeal shock wave therapy(control group),and 50 cases were treated with qianlieshutong capsule combined with extracorporeal shock wave therapy(observation group).The National Institutes of Healthy chronic prostatitis symptom index(NIH-CPSI),interleukin(IL)-6,IL-8,tumor necrosis factor(TNF)-α,T lymphocyte subsets,small particle of lecithin(SPL)and prostate specific antigen(PSA)before and after treatment were compared between 2 groups.The adverse reactions and efficacy were compared between 2 groups.Results The total effective rate in observation group was significantly higher than that in control group:88.0%(44/50)vs.70.0%(35/50),and there was statistical difference(χ^(2)=4.88,P<0.05).There were no significant differences in NIH-CPSI respective scores and total score before treatment between 2 groups(P>0.05);the NIH-CPSI respective scores of pain and discomfort,urination,symptoms,quality of life and total score after treatment in observation group were significantly lower than those in control group:(4.15±1.04)scores vs.(6.72±1.13)scores,(1.23±0.39)scores vs.(1.88±0.48)scores,(1.31±0.39)scores vs.(1.91±0.35)scores,(1.68±0.34)scores vs.(2.35±0.32)scores and(8.37±1.02)scores vs.(12.86±1.33)scores,and there were statistical differences(P<0.01).There were no statistical differences in the prostatic fluid and serum IL-6,IL-8 and TNF-αbefore treatment between 2 groups(P>0.05);the prostatic fluid and serum IL-6,IL-8 and TNF-αafter treatment in observation group were significantly lower than those in control group,and there were statistical differences(P<0.01).There were no statistical difference in CD_(3)^(+),CD_(4)^(+),C

关 键 词：前列腺炎 高能量冲击波 免疫 前列舒通胶囊 炎性因子 

分 类 号：R697.33[医药卫生—泌尿科学]