心肌细胞钙稳态失调在心力衰竭中作用的研究进展  

Research progress on the role of myocardial cell calcium homeostasis dysregulation in heart failure

作　　者：刘峰宇 韩薇[1] LIU Feng-yu;HAN Wei(Department of Cardiology,the First Affliated Hospital of Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第一医院心血管内科,黑龙江哈尔滨150000

出　　处：《基础医学与临床》2022年第3期502-506,共5页Basic and Clinical Medicine

基　　金：黑龙江省自然科学基金(ZD2020H002);上海市浦东新区卫生系统重点学科项目(PWZxk2017-01)。

摘　　要：心肌细胞的钙稳态依赖于质膜、肌/内质网(SR)、线粒体等对钙(Ca^(2+))转运的调节。胞质钙超载、SR钙渗漏等在内的钙稳态失调,使心肌细胞钙瞬变减低,收缩力下降是心力衰竭的主要特征之一。Calcium homeostasis of cardiomyocytes depends on the regulation of calcium(Ca^(2+))transportation through plasma membrane,sarco/endoplasmic reticulum(SR)and mitochondria.One of the main characteristics of heart failure is calcium homeostasis,including cytosolic calcium overload and SR calcium leakage,which leads to transient decrease of myocardial calcium and decrease of contractility.

关 键 词：钙稳态 心力衰竭 钙ATP酶2a 2型兰尼碱受体(RyR2) 

分 类 号：R541[医药卫生—心血管疾病]