局部麻醉药物在肿瘤转移和复发中作用的研究进展  

Research advances in the roles of local anesthetics in tumor metastasis and recurrence

作　　者：刘畅[1] 郭向阳[1] LIU Chang;GUO Xiang-yang(Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China)

机构地区：[1]北京大学第三医院麻醉科,北京100191

出　　处：《基础医学与临床》2022年第3期512-515,共4页Basic and Clinical Medicine

基　　金：北京大学第三医院院临床重点支持项目(BYSY2017001)。

摘　　要：围术期肿瘤治疗常需要使用麻醉药物。不同麻醉药物及麻醉方法的选择会影响肿瘤的增殖、转移复发及预后。围术期应用局部麻醉药物(简称局麻药)不仅能减少阿片类药物的用量,尚能通过阻滞肿瘤细胞钠通道、改变表观遗传学、减轻炎性反应和提高免疫功能等机制发挥抑制肿瘤转移和复发的作用。探讨局麻药在肿瘤转移复发中的作用机制,可为围术期肿瘤患者局麻药的合理使用提供新的策略。Anesthetics are commonly used in the perioperative treatment of tumor.The choice of different anesthetics and anesthesia techniques will affect the proliferation,metastasis,recurrence and prognosis of cancer.Perioperative applications of local anesthetics can not only reduce the amount of opioids,but also inhibit tumor metastasis and recurrence by blocking sodium channels of cancer cells,changing epigenetics,decreasing inflammation and improving immune function.The exploration of the mechanism of local anesthetics in tumor metastasis and recurrence provides the new strategies for the optimal use of local anesthetics in cancer patient's perioperatively chemotherapy.

关 键 词：麻醉 肿瘤 局部麻醉药物 转移和复发 

分 类 号：R614[医药卫生—麻醉学]