心肌肥大表观遗传调控的研究进展  

Progress in the study of the epigenetic regulation of cardiac hypertrophy

作　　者：郑婧婧 卜宁 赵钊 张佳靖 于慧[1] 赵宇航 ZHENG Jing-jing;BU Ning;ZHAO Zhao;ZHANG Jia-jing;YU Hui;ZHAO Yu-hang(Baotou Medical College,Baotou 014000;Inner Mongolia Baotou Steel Sanatorium,Baotou 014000,China)

机构地区：[1]包头医学院,内蒙古包头014000 [2]内蒙古包钢疗养院,内蒙古包头014000

出　　处：《基础医学与临床》2022年第3期520-524,共5页Basic and Clinical Medicine

基　　金：内蒙古自然科学基金(2017BS0301);内蒙古教育厅科技项目(NJZY17260);包头医学院扬帆计划(BYJJ-YF201625);内蒙古自治区商校“青年科技英才”支持计划(NJYT-20-B34);包头医学院研究生科研创新项目(bycx2020005)。

摘　　要：心肌肥大是各种严重心血管疾病的独立危险因素。表观遗传学涉及的机制,如DNA甲基化、组蛋白修饰、RNA甲基化等参与心肌肥大的发生发展。因此,了解表观遗传对心肌肥大的作用有助于为心肌肥大的预防和早期治疗提供有效方案和科学依据。Myocardial hypertrophy is an independent risk factor for various serious cardiovascular diseases.Epigenetic mechanisms such as DNA methylation,histone modification,and RNA methylation are involved in the pathogenesis and development of cardiac hypertrophy.To understanding the role of epigenetic regulation on cardiac hypertrophy contributes to to development of an effective protocol and provide scientific basis for the prevention and early treatment of cardiac hypertrophy.

关 键 词：心肌肥大 表观遗传学 非编码RNA DNA甲基化 组蛋白修饰 

分 类 号：R34[医药卫生—基础医学]