体重指数对多囊卵巢综合征和输卵管因素不孕患者行IVF-ET治疗结局的影响  

Objective to analyze the influence of body mass index on the outcome of infertility patients with polycystic ovary syndrome and tubal factors treated by IVF-ET

作　　者：冯玉环[1] 周巧兰[1] 晏红伟 栗凤霞 樊桂玲 FENG Yuhuan;ZHOU Qiaolan;YAN Hongwei;LI Fengxia;FAN Guiling(Tangshan Maternal and Child Health Care Hospital,Tangshan,Hebei 063000,China;Xingtai Maternal and Child Health Hospital,Xingtai,Hebei 054000,China;Tangshan Central Hospital,Tangshan,Hebei 063000,China)

机构地区：[1]河北省唐山市妇幼保健院,063000 [2]河北省邢台市妇幼保健院,054000 [3]河北省唐山市中心医院,063000

出　　处：《重庆医学》2021年第S02期43-45,共3页Chongqing medicine

基　　金：2020年度河北省医学科学研究课题计划(20201483)。

摘　　要：目的探讨体重指数(BMI)对多囊卵巢综合征和输卵管因素不孕患者行体外受精-胚胎移植(IVF-ET)治疗结局的影响。方法选取2019年9月至2020年12月河北省唐山市妇幼保健院收治的行IVF-ET治疗的不孕患者270例,其中135例体重正常者(BMI<24 kg/m^(2))作为观察组,135例肥胖者(BMI≥24 kg/m^(2))作为对照组。比较两组患者的治疗结局。结果观察组患者优质胚胎率、临床妊娠率均明显高于对照组,自然流产率明显低于对照组,子宫内膜厚度比对照组薄,人绒毛膜促性腺激素日P及E2水平比对照组低,促性腺激素使用量比对照组少,促性腺激素使用时间比对照组短,差异均有统计学意义(P<0.05);两组患者移植胚胎率、胚胎种植率、生化妊娠率比较,差异均无统计学意义(P>0.05)。结论无论是多囊卵巢综合征造成的不孕,还是输卵管因素造成的不孕,在IVF-ET治疗过程中妊娠结局均会受BMI的影响。所以,建议为患者提供及时、准确地治疗,积极调节BMI,升高子宫内膜容受性,从而提高妊娠率,降低流产率。Objective To analyze the effect of body mass index(BMI)on the treatment outcome of infertility patients undergoing in vitro fertilization-embryo transfer(IVF-ET)due to polycystic ovary syndrome(PCOS)and fallopian tube factors.Methods The study started from September 2019 to December 2020.The subjects selected for this study were 270 infertile patients who underwent IVF-ET treatment in our hospital during the same period.135 patients with normal weight(BMI<24 kg/m^(2))were in the observation group,and 135 patients with obesity(BMI≥24 kg/m^(2))were in the control group.Compare the treatment outcome of each group.Results The high-quality embryo rate in the observation group was 30.37%,and the clinical pregnancy rate was 54.07%,which were higher than those in the control group,18.52%and 40.74%,respectively,with significant differences(P<0.05).The spontaneous abortion rate in the observation group was 6.67%,which was lower than 14.84%in the control group,and the difference was significant(P<0.05).The endometrial thickness of the observation group was thinner than that of the control group,the levels of P and E2 on hCG days were lower than that of the control group,the amount of GN was less than that of the control group,and the GN days were shorter than that of the control group(the data and the table were consistent and needed to be modified),the differences were significant(P<0.05).There was no difference between the transferable embryo rate,embryo implantation rate,and biochemical pregnancy rate(P>0.05).Conclusion Whether PCOS causes infertility or fallopian tube factors,the pregnancy outcome will be affected by body mass index during IVF-ET treatment.Therefore,it is recommended to provide patients with timely and accurate treatment,actively adjust the body mass index,and increase the receptivity of the endometrium,thereby increasing the pregnancy rate and reducing the miscarriage rate.

关 键 词：体重指数 多囊卵巢综合征 输卵管 体外受精-胚胎移植 不孕 

分 类 号：R71[医药卫生—妇产科学]