有机磷酸酯阻燃剂的人群暴露和甲状腺毒性的研究进展  

A review of organophosphate esters(OPEs):Human exposure and toxicities in thyroid

作　　者：顾俊婕 胡曼 耿阳 柏品清 周颖[1,2,3] GU Junjie;HU Man;GENG Yang;BAI Pinqing;ZHOU Yin(Centers for Water and Health,Key Laboratory of Public Health Safety,Ministry of Education,Fudan University,Shanghai,200032,China;Department of Chemistry in Public Health Science,School of Public Health,Fudan University,Shanghai,200032,China;Pudong New Area for Disease Control and Prevention,Fudan University Pudong Institute of Preventive Medicine,Shanghai,200136,China)

机构地区：[1]复旦大学教育部公共卫生安全教育部重点实验室,复旦大学公共卫生学院饮水与健康研究中心,上海200032 [2]复旦大学公共卫生学院营养与食品卫生学暨卫生化学教研室,上海200032 [3]复旦大学浦东预防医学研究院,上海市浦东新区疾病预防控制中心,上海200136

出　　处：《环境化学》2022年第1期31-45,共15页Environmental Chemistry

基　　金：国家重点研发计划(2017YFC1600500);国家自然科学基金(81373089)资助.

摘　　要：有机磷酸酯(organophosphate esters,OPEs)是使用最为广泛的有机磷阻燃剂,并兼具增塑剂、消泡剂和萃取剂等功能,被广泛用于电子产品、建筑材料和塑料材料等中,导致其在环境介质中普遍存在,对生态系统和人体健康构成巨大威胁。作为一种新型环境污染物,OPEs的人群暴露特征和生物毒性成为环境健康领域的研究热点。本文系统综述了OPEs的人群暴露特征和甲状腺毒性的研究进展,最后对存在的问题和未来研究方向进行了分析和展望。Organophosphate esters(OPEs)are the most widely used organophosphorus flame retardant and has the functions of plasticizer,defoamer and extractant,added in electronic products,building materials and plastic materials,etc.The widespread use of OPEs has resulted in their ubiquitous occurrence in environmental media,which pose a threat to both ecosystems and human health.As a type of emerging environmental pollutants,human exposure to OPEs and related toxicity have become a research hotpot in the field of environmental health.In this paper,the research progresses on the population exposure to several kinds of OPEs and its toxicities in thyroid system were summarized.Finally,the gaps in our knowledge of human exposure assessment and thyroid toxicity of OPEs were highlighted and critical directions for future studies were proposed.

关 键 词：有机磷酸酯 人群暴露 甲状腺毒性 有机磷阻燃剂 

分 类 号：R99[医药卫生—毒理学] X503.1[医药卫生—药学]