类风湿关节炎常用药物治疗方案及进展  

Treatment and progress of common drugs for rheumatoid arthritis

作　　者：陈金堂 王波[1] 季卫平[1] CHEN Jintang;WANG Bo;JI Weiping(The Fourth Department of Orthopaedics,Lishui People's Hospital,Lishui 323000,China)

机构地区：[1]丽水市人民医院骨科四病区,浙江丽水323000

出　　处：《中国现代医生》2022年第3期193-196,共4页China Modern Doctor

基　　金：浙江省基础公益研究计划(LGD20H060001)。

摘　　要：类风湿性关节炎(RA)是一种以非化脓性增生性滑膜炎为主的对称性自身免疫性疾病,最初会影响小关节,逐渐发展为大关节,最后影响皮肤、眼睛、心脏、肾脏和肺部。RA发病机制特殊,目前虽诊疗手段繁多,却暂无完美诊疗手段。现有的用于治疗RA的药物诸如甲氨蝶呤类慢性抗风湿类药物(DMARDs)、类固醇(GC)、非类固醇消炎药(NSAIDs),TNF因子抑制剂(TNF inhibitor)以及新型药剂载体如聚合物胶体(Polymer colloids)等。传统药物治疗上虽有明确控制症状及适应范围的优势,然具有较大毒副作用,以GCs尤为突出。除这些药物治疗RA之外,手术治疗及其他方式的治疗如心理干预治疗等有待研究。故本文参考各大文献数据库中最新的相关文献作一简短综述。Rheumatoid arthritis(RA)is a symmetric autoimmune disease dominated by non-suppurative proliferative synovitis,which initially affects small joints,gradually develops into large joints,and finally affects the skin,eyes,heart,kidney,and lung.The pathogenesis of RA is special.Although there are many diagnosis and treatment methods,there is no perfect diagnosis and treatment method.Existing drugs for the treatment of RA include disease-modifying anti-rheumatic drugs(DMARDs),steroids(GC),nonsteroidal anti-inflammatory drugs(NSAIDs),TNF inhibitors,and new drug carriers such as polymer colloids.Although traditional drugs have the advantages of explicit control of symptoms and adaptation range,they have significant side effects,especially GCs.In addition to these drugs for RA treatment,surgical treatment and other treatments such as psychological intervention therapy need to be studied.Therefore,this article does a brief review regarding the latest relevant documents in major literature databases.

关 键 词：非类固醇消炎药 慢性抗风湿类药物 糖皮质激素 TNF因子抑制剂 聚合物胶体 

分 类 号：R612[医药卫生—外科学]