静脉滴注溴己新联合沙丁胺醇雾化治疗AECOPD的临床观察  

Clinical observation of Bromhexine combined with Salbutamol atomization in the treatment of AECOPD

作　　者：彭宁[1] Pen Ning(The First People's Hospital of Guiyang City,Guiyang,Guizhou 550002)

机构地区：[1]贵阳市第一人民医院,贵州贵阳550002

出　　处：《基层医学论坛》2022年第4期8-10,16,共4页The Medical Forum

摘　　要：目的观察静脉滴注溴己新联合沙丁胺醇雾化治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法选取2018年1月-2019年12月在贵阳市第一人民医院呼吸内科收治的120例AECOPD患者为研究对象,按照随机数字表法分为对照组和观察组,每组各60例,对照组在常规治疗基础上给予静脉滴注渙己新,观察组则给予静脉滴注涣己新联合沙丁胺醇雾化,观察记录治疗15 d后的肺功能指标、血气指标、毎天痰液总量以及体征消失时间、疗效。结果观察组术后肺功能指标FEV_(1)、FVC、FEV_(1)/FVC明显优于对照组(P<0.05);2组治疗后的血气指标相比于治疗前均有所改善,且观察组治疗后PaO_(2)、pH、SaO_(2)高于对照组,PaCO_(2)低于对照组,差异显著(P<0.05);观察组痰液量明显少于对照组,且观察组临床相关症状(咳嗽、喘息、肺部啰音)消失情况明显快于对照组(P<0.05);观察组总有效率高于对照组(P<0.05)。结论赫脉滴注溴己新联合沙丁胺醇雾化治疗AECOPD疗效显著,可明显改善患者肺功能与血气指标、促进排痰、缩短呼吸道症状持续时间,值得推广。Objective To observe the clinical effect of bromhexine combined with salbutamol atomization in the treatment of AECOPD.Methods 120 cases of AECOPD patients in our hospital from January 2018 to December 2019 were selected as the research objects,and they were randomly divided into the control group and the observation group according to the number table method,with 60 cases in each group.The control group was given intravenous bromhexine on the basis of conventional treatment,and the observation group was given intravenous bromhexine combined with albuterol atomization.The pulmonary function was observed and recorded after 15 days of treatment Index,Blood gas index,total amount of sputum per day and disappearance time of signs.Results In the observation group,FEV_(1),FVC,FEV_(1)were the indexes of pulmonary function/FVC was significantly better than that of the control group(P<0.05);The blood gas indexes of the two groups after treatment were improved compared with those before treatment,and PaO_(2),pH and SaO_(2)of the observation group were higher than those of the control group after treatment,while PaCO_(2)was lower than that of the control group,so the data improvement had more advantages(P<0.05);The amount of sputum in the observation group was significantly less than that in the control group,and the clinical related symptoms(cough,wheezing and pulmonary rales)disappeared significantly faster in the observation group tlian in the control group(P<0.05).Conclusion Intravenous drip of bromhexin combined with salbutamol atomization in the treatment of AECOPD has a significant effect,shich can significantly improve the lung function and blood gas indexes,promote sputum excretion and shorten the duration of respiratory symptoms,which is worthy of clinical application.

关 键 词：慢性阻塞性肺疾病急性加重期 溴己新 沙丁胺醇 临床疗效 

分 类 号：R563.9[医药卫生—呼吸系统]