卵巢早衰相关发病因素的病例对照研究  

A Case-control Study on Related Factors of Premature Ovarian Failure

作　　者：王睿[1] 沙仁高娃[2] WANG Rui;SHA Rengaowa(Department of Gynecology,Qinghai Red Cross Hospital,Xining 810000,Qinghai,China;Department of Gynecology,Affiliated Hospital of Qinghai University,Xining 810000,Qinghai,China)

机构地区：[1]青海红十字医院妇科,青海西宁810000 [2]青海大学附属医院妇科,青海西宁810000

出　　处：《医学信息》2022年第3期95-98,共4页Journal of Medical Information

摘　　要：目的探讨卵巢早衰的相关发病因素。方法以2020年5月-2021年5月青海红十字医院妇科确诊的123例卵巢早衰患者为研究对象,设为卵巢早衰组,另选取120例同期体检健康女性设为健康对照组,调查并统计其一般资料,分析卵巢早衰的发病因素。结果单因素分析显示,卵巢早衰组与健康对照组卵巢早衰家族史、绝经前1年月经规律性、人工流产数、吸烟、过度减重、生活不规律、精神刺激、情绪抑郁、放化疗、腹部手术因素比较,差异有统计学意义(P<0.05);经多因素Logistic分析可知,负性精神刺激(OR=7.134,95%CI:5.427~9.458)、过度减重(OR=3.036,95%CI:2.218~6.185)、生活不规律(OR=1.822,95%CI:1.042~3.528)、情绪抑郁(OR=1.777,95%CI:1.183~5.279)、卵巢早衰家族史(OR=1.854,95%CI:3.276~7.831)、人工流产数≥4次(OR=1.856,95%CI:1.103~3.749)、吸烟(OR=1.073,95%CI:0.876~3.635)、绝经前1年月经不规律(OR=5.235,95%CI:1.024~3.572)、放化疗(OR=3.488,95%CI:2.161~6.737)、腹部手术(OR=2.577,95%CI:1.367~5.739)均是引起卵巢早衰的危险因素。结论卵巢早衰的发生与精神刺激、情绪抑郁、过度减重、生活不规律、卵巢早衰家族史、人工流产次数、月经不规律、放化疗、腹部手术因素有关,应提高对该病的认识,积极预防卵巢早衰的发生。Objective To explore the related pathogenic factors of premature ovarian failure.Methods A total of 123 patients with premature ovarian failure diagnosed in the department of gynecology of Qinghai Red Cross Hospital from May 2020 to May 2021 were selected as the premature ovarian failure group,and 120 healthy women in the same period were selected as the healthy control group.The general data were investigated and counted,and the pathogenic factors of premature ovarian failure were analyzed.Results Univariate analysis showed that there were statistically significant differences in the family history of premature ovarian failure,menstrual regularity one year before menopause,the number of abortions,smoking,excessive weight loss,irregular life,mental stimulation,emotional depression,radiotherapy and chemotherapy,and abdominal surgery between the premature ovarian failure group and the healthy control group(P<0.05).Multivariate Logistic analysis showed that negative mental stimulation(OR=7.134,95%CI:5.427-9.458),excessive weight loss(OR=3.036,95%CI:2.218-6.185),irregular life(OR=1.822,95%CI:1.042-3.528),emotional depression(OR=1.777,95%CI:1.183-5.279),family history of premature ovarian failure(OR=1.854,95%CI:3.276-7.831),number of abortions≥4(OR=1.856,95%CI:1.103-3.749),smoking(OR=1.073,95%CI:0.876-3.635),irregular menstruation 1 year before menopause(OR=5.235,95%CI:1.024-3.572),chemoradiotherapy(OR=3.488,95%CI:2.161-6.737)and abdominal surgery(OR=2.577,95%CI:1.367-5.739)were risk factors for premature ovarian failure.Conclusion The occurrence of premature ovarian failure is related to mental stimulation,emotional depression,excessive weight loss,irregular life,family history of premature ovarian failure,number of abortions,irregular menstruation,radiotherapy and chemotherapy,abdominal surgery.It is necessary to improve the understanding of the disease and actively prevent the occurrence of premature ovarian failure.

关 键 词：卵巢早衰 血清卵泡刺激 黄体生成素 流产 

分 类 号：R711.5[医药卫生—妇产科学]