自噬与复发性流产关系的研究进展  

Research Progress of Autophagy and Recurrent Abortion

作　　者：孙佳宁[1] 冯晓玲[2] 赵小萱 李波[3] SUN Jianing;FENG Xiaoling;ZHAO Xiaoxuan;LI Bo(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Gynecology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Rehabilitation,the Third Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150030,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院妇科,哈尔滨150040 [3]黑龙江中医药大学附属第三医院康复科,哈尔滨150030

出　　处：《医学综述》2022年第4期660-665,共6页Medical Recapitulate

基　　金：国家自然科学基金(81973894)。

摘　　要：自噬普遍存在于真核细胞的自我降解过程中,受多种分子机制调控,已成为近年细胞死亡途径的研究热点之一。自噬的生理功能包括提供能量、维持细胞内环境稳定和促进异常细胞凋亡。近年来,复发性流产(RSA)因发病率逐年升高而受到关注。自噬作用参与RSA的发生和发展,自噬异常在RSA中的病理机制逐渐受到学术界的广泛关注。此外,自噬还参与母胎界面中滋养细胞侵袭和蜕膜化过程,因此调控RSA母胎界面自噬功能的平衡成为防治RSA的主要靶点之一。Autophagy generally exists in the self-degradation process of eukaryotic cells and is regulated by a variety of molecular mechanisms,which has become one of the research hotspots of cell death pathway in recent years.The physiological functions of autophagy include providing energy,maintaining the stability of intracellular environment and promoting abnormal cell apoptosis.In recent years,recurrent spontaneous abortion(RSA)has been paid attention due to the increasing incidence.Autophagy is involved in the occurrence and development of RSA.The pathological mechanism of abnormal autophagy in RSA has gradually attracted extensive attention in academic circles.In addition,autophagy is also involved in trophoblast invasion and decidualization in the maternal fetal interface.Therefore,regulating the balance of autophagy function in the maternal fetal interface has become one of the main targets for the prevention and treatment of RSA.

关 键 词：复发性流产 自噬 滋养细胞 蜕膜细胞 

分 类 号：R271[医药卫生—中医妇科学]