Highly Stereocontrolled Total Syntheses of Cedrane Sesquiterpenes via Cascade [5+2] Cycloaddition/Etherification  

作　　者：Yuhan Zhang Zhiyong Chi Xiangxin Li Zhixiang Xie 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry&College of Chemistry and Chemical Engineering,Lanzhou University,222 Tianshui South Road,Lanzhou,Gansu 730000,China

出　　处：《Chinese Journal of Chemistry》2022年第2期183-189,共7页中国化学（英文版）

基　　金：Financial support from the National Natural Science Founda-tion of China(Nos.21971096,21772079,&21672088);the Natural Science Foundation of Gansu Province(No.18JR4RA003)is acknowledged.

摘　　要：Cedrane sesquiterpenes possess common tricyclo[5.3.1.0^(1,5)]undecane core structure.The varied oxa-five-membered ring decorating their core structure to form 8-oxa-tetracyclo[7.2.2.0^(1,5).0^(6,13)]tridecane framework,containing six consecutive chiral centers(including two all-carbon quaternary centers and one oxygenated quaternary carbon center),has proven to be a synthetic challenge and a biosynthetic mystery to date.

关 键 词：TERPENOIDS Asymmetric synthesis DEHYDROGENATION Cascade[5+2]cycloaddition/etherification Protecting group-free 

分 类 号：O62[理学—有机化学]